Article
IC50 of trifluoperazine and RMI 12330A for the Theophylline and Phloretin - lnduced lncrease in Intestinal D-Galactose Accumulation
Author/s | Ilundáin Larrañeta, María Anunciación Ana
Alcalde Herrero, Ana Isabel Barcina Angulo, Yolanda Larralde, J. |
Department | Universidad de Sevilla. Departamento de Fisiología |
Publication Date | 1987 |
Deposit Date | 2016-01-20 |
Published in |
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Abstract | The effect of trifluoperazine and RMI 12330A on D-Galactose accumulation was studied in
isolated rat intestinal mucosa. Both drugs inhibited the theophylline and phloretin-induced
increase in tissue sugar accumulation ... The effect of trifluoperazine and RMI 12330A on D-Galactose accumulation was studied in isolated rat intestinal mucosa. Both drugs inhibited the theophylline and phloretin-induced increase in tissue sugar accumulation in a concentration-dependent fashion, with IC50 values close to 10- 6 M. These findings suggest that calmodulin might mediate the theophylline and phloretin actions on galactose transpon in intact rat ilcum. |
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