Artículo
Pretreatment with Oleuropein Protects the Neonatal Brain from Hypoxia-ischemia by Inhibiting Apoptosis and Neuroinflammation
Autor/es | Reyes Corral, Marta
Gil González, Laura González Díaz, Ángela Tovar Luzón, Javier Ayuso, María Irene Lao Pérez, Miguel Montaner, Joan Puerta Vázquez, Rocío de la Fernández Torres, Rut Ybot González, Patricia |
Departamento | Universidad de Sevilla. Departamento de Química Analítica Universidad de Sevilla. Departamento de Farmacología |
Fecha de publicación | 2024 |
Fecha de depósito | 2024-09-26 |
Publicado en |
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Resumen | Hypoxic-ischemic (HI) encephalopathy is a cerebrovascular injury caused by oxygen deprivation to the brain and remains a major cause of neonatal mortality and morbidity worldwide. Therapeutic hypothermia is the current ... Hypoxic-ischemic (HI) encephalopathy is a cerebrovascular injury caused by oxygen deprivation to the brain and remains a major cause of neonatal mortality and morbidity worldwide. Therapeutic hypothermia is the current standard of care but it does not provide complete neuroprotection. Our aim was to investigate the neuroprotective effect of oleuropein (Ole) in a neonatal (seven-day-old) mouse model of HI. Ole, a secoiridoid found in olive leaves, has previously shown to reduce damage against cerebral and other ischemia/reperfusion injuries. Here, we administered Ole as a pretreatment prior to HI induction at 20 or 100 mg/kg. A week after HI, Ole significantly reduced the infarct area and the histological damage as well as white matter injury, by preserving myelination, microglial activation and the astroglial reactive response. Twenty-four hours after HI, Ole reduced the overexpression of caspase-3 and the proinflammatory cytokines IL-6 and TNF-α. Moreover, using UPLC-MS/MS we found that maternal supplementation with Ole during pregnancy and/or lactation led to the accumulation of its metabolite hydroxytyrosol in the brains of the offspring. Overall, our results indicate that pretreatment with Ole confers neuroprotection and can prevent HI-induced brain damage by modulating apoptosis and neuroinflammation. |
Agencias financiadoras | Junta de Andalucía European Union (UE) |
Identificador del proyecto | DOC_01701
P20_01267 RH-0033-2020 C-0025-2018 PI20/00769 |
Cita | Reyes Corral, M., Gil González, L., González Díaz, Á., Tovar Luzón, J., Ayuso, M.I., Lao Pérez, M.,...,Ybot González, P. (2024). Pretreatment with Oleuropein Protects the Neonatal Brain from Hypoxia-ischemia by Inhibiting Apoptosis and Neuroinflammation. Journal of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X241270237. |
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