Chapter of Book
Coupling Between Messenger RNA Synthesis and Degradation during Genome Expression
Author/s | Chávez de Diego, Sebastián
Pérez Aguado, David Chávez de Diego, María José Romero Campero, Francisco José |
Department | Universidad de Sevilla. Departamento de Genética Universidad de Sevilla. Departamento de Matemática Aplicada I (ETSII) Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial |
Publication Date | 2015 |
Deposit Date | 2024-09-23 |
ISBN/ISSN | 978-84-617-9075-3 |
Abstract | Genome expression involves the synthesis of messenger RNA (mRNA), a short lived molecule whose translation directs the synthesis of cellular proteins and that is
subject to degradation after the translation process. Up ... Genome expression involves the synthesis of messenger RNA (mRNA), a short lived molecule whose translation directs the synthesis of cellular proteins and that is subject to degradation after the translation process. Up to the date, mRNA synthesis and degradation has been considered as a linear phenomenon in which the above steps occur subsequently without a regulatory interconnection. However, gene expression can be studied as a global system in which all their stages are coupled and interconnected by regulatory mechanisms. We have contributed to demonstrate that the machineries of mRNA synthesis and degradation physically and functionally interact in the cell nucleus. We have proposed that it allows the cross-regulation of transcription with mRNA degradation and vice versa, giving rise to a circular system, which would explain the large robustness observed in gene expression (Haimovich et al, 2013). |
Funding agencies | Junta de Andalucía |
Project ID. | eCompleXcity Project TIC-6064 |
Citation | Chávez de Diego, S., Pérez Aguado, D., Chávez de Diego, M.J. y Romero Campero, F.J. (2015). Coupling Between Messenger RNA Synthesis and Degradation during Genome Expression. |
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