Artículo
Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia
Autor/es | Caballero Eraso, Candela
Colinas Miranda, Olalla González Montelongo, Rafaela Cabeza, Jose M. Gao Chen, Lin Pardal Redondo, Ricardo López Barneo, José Ortega Sáenz, Patricia |
Departamento | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica Instituto de Biomedicina de Sevilla (IBIS) |
Fecha de publicación | 2023-01-17 |
Fecha de depósito | 2024-09-17 |
Publicado en |
|
Resumen | The carotid body (CB) is a prototypical acute oxygen (O2)-sensing organ that mediates reflex hyperventilation and increased cardiac output in response to hypoxaemia. CB overactivation, secondary to the repeated stimulation ... The carotid body (CB) is a prototypical acute oxygen (O2)-sensing organ that mediates reflex hyperventilation and increased cardiac output in response to hypoxaemia. CB overactivation, secondary to the repeated stimulation produced by the recurrent episodes of intermittent hypoxia, is believed to contribute to the pathogenesis of sympathetic hyperactivity present in sleep apnoea patients. Although CB functional plasticity induced by chronic intermittent hypoxia (CIH) has been demonstrated, the underlying mechanisms are not fully elucidated. Here, we show that CIH induces a small increase in CB volume and rearrangement of cell types in the CB, characterized by a mobilization of immature quiescent neuroblasts, which enter a process of differentiation into mature, O2-sensing and neuron-like, chemoreceptor glomus cells. Prospective isolation of individual cell classes has allowed us to show that maturation of CB neuroblasts is paralleled by an upregulation in the expression of specific glomus cell genes involved in acute O2-sensing. CIH enhances mitochondrial responsiveness to hypoxia in maturing neuroblasts as well as in glomus cells. These data provide novel perspectives on the pathogenesis of CB-mediated sympathetic overflow that may lead to the development of new pharmacological strategies of potential applicability in sleep apnoea patients. |
Agencias financiadoras | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Junta de Andalucía. Consejería de Salud Ministerio de Ciencias, Innovación y Salud. |
Identificador del proyecto | PI-0125-2016
PID2019-106410RB-I00 PID2019-110817R |
Cita | Caballero Eraso, C., Colinas Miranda, O., González Montelongo, R., Cabeza, J.M., Gao Chen, L., Pardal Redondo, R.,...,Ortega Sáenz, P. (2023). Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia. Journal of physiology-London, 601 (5), 1017-1036. https://doi.org/10.1113/JP283897. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Acreditación y articulo Rearra ... | 4.923Mb | [PDF] | Ver/ | |
Este registro aparece en las siguientes colecciones
Este documento está protegido por los derechos de propiedad intelectual e industrial. Sin perjuicio de las exenciones legales existentes, queda prohibida su reproducción, distribución, comunicación pública o transformación sin la autorización del titular de los derechos, a menos que se indique lo contrario.