Artículo
Asymmetric Synthesis of Axially Chiral C N Atropisomers
Autor/es | Rodríguez Salamanca, Patricia
Fernández Fernández, Rosario Fátima Hornillos, Valentín Lassaletta, José M. |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2022 |
Fecha de depósito | 2024-08-30 |
Publicado en |
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Resumen | Molecules with restricted rotation around a single
bond or atropisomers are found in a wide number of natural
products and bioactive molecules as well as in chiral ligands
for asymmetric catalysis and smart materials. ... Molecules with restricted rotation around a single bond or atropisomers are found in a wide number of natural products and bioactive molecules as well as in chiral ligands for asymmetric catalysis and smart materials. Although most of these compounds are biaryls and heterobiaryls displaying a C C stereogenic axis, there is a growing interest in less common and more challenging axially chiral C N atropisom- ers. This review offers an overview of the various method- ologies available for their asymmetric synthesis. A brief introduction is initially given to contextualize these axially chiral skeletons, including a historical background and examples of natural products containing axially chiral C N axes. The preparation of different families of C N based atropisomers is then presented from anilides to chiral five- and six-membered ring heterocycles. Special emphasis has been given to modern catalytic asymmetric strategies over the past decade for the synthesis of these chiral scaffolds. Applications of these methods to the preparation of natural products and biologically active molecules will be highlighted along the text. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía |
Identificador del proyecto | PID2019-106358GB-C21
PID2019-106358GB-C22 RYC-2017-22294 BES-2017-081561 P18-FR-3531 P18-FR-644 US-1262867 US-1260906 |
Cita | Rodríguez Salamanca, P., Fernández Fernández, R.F., Hornillos, V. y Lassaletta, J.M. (2022). Asymmetric Synthesis of Axially Chiral C N Atropisomers. Chemistry – A European Journal, 28 (28), e202104442. https://doi.org/10.1002/chem.202104442. |
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