Article
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
Author/s | Luna Varo, Rosa María
Gómez González, Belén Aguilera López, Andrés |
Department | Universidad de Sevilla. Departamento de Genética |
Publication Date | 2024-07 |
Deposit Date | 2024-08-21 |
Published in |
|
Abstract | Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more than four decades, transcription enhances mutation and recombination frequencies. More recent research provided evidence for a previously ... Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more than four decades, transcription enhances mutation and recombination frequencies. More recent research provided evidence for a previously unforeseen link between RNA and DNA metabolism, which is often related to the accumulation of DNA–RNA hybrids and R-loops. In addition to physiological roles, R-loops interfere with DNA replication and repair, providing a molecular scenario for the origin of genome instability. Here, we review current knowledge on the multiple RNA factors that prevent or resolve R-loops and consequent transcription–replication conflicts and thus act as modulators of genome dynamics. |
Funding agencies | Ministerio de Ciencia e Innovación (MICIN). España Agencia Estatal de Investigación. España European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Fundación Caixa de Investigación. España Junta de Andalucía |
Project ID. | PID2022- 138251NB-I00
LCF/PR/HR22/52420014 |
Citation | Luna Varo, R.M., Gómez González, B. y Aguilera López, A. (2024). RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.. Genes & Development, 38 (11-12), 504-527. https://doi.org/10.1101/gad.351853.124.. |
Files | Size | Format | View | Description |
---|---|---|---|---|
Genes Dev.-2024-Luna-504-27.pdf | 644.7Kb | [PDF] | View/ | |