Artículo
Foetal gluten immunogenic peptides during pregnancy: a new determinant on the coeliac exposome.
Autor/es | Moreno Amador, María de Lourdes
González Rovira, María Martínez Pancorbo, Cristina Martín Cameán, María Najar Moyano, Ana María Romero, Mercedes Mellado Durán, María Encarnación Sáinz Bueno, José Antonio Sousa Martín, Carolina |
Departamento | Universidad de Sevilla. Departamento de Cirugía Universidad de Sevilla. Departamento de Microbiología y Parasitología |
Fecha de publicación | 2024-07-18 |
Fecha de depósito | 2024-07-23 |
Publicado en |
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Resumen | Background
The increasing incidence of coeliac disease is leading to a growing interest in active search for associated factors, even the intrauterine and early life. The exposome approach to disease encompasses a life ... Background The increasing incidence of coeliac disease is leading to a growing interest in active search for associated factors, even the intrauterine and early life. The exposome approach to disease encompasses a life course perspective from conception onwards has recently been highlighted. Knowledge of early exposure to gluten immunogenic peptides (GIP) in utero could challenge the chronology of early prenatal tolerance or inflammation, rather than after the infant’s solid diet after birth. Methods We developed an accurate and specific immunoassay to detect GIP in amniotic fluid (AF) and studied their accumulates, excretion dynamics and foetal exposure resulting from AF swallowing. One hundred twenty-five pregnant women with different gluten diets and gestational ages were recruited. Results GIP were detectable in AF from at least the 16th gestational week in gluten-consuming women. Although no significant differences in GIP levels were observed during gestation, amniotic GIP late pregnancy was not altered by maternal fasting, suggesting closed-loop entailing foetal swallowing of GIP-containing AF and subsequent excretion via the foetal kidneys. Conclusions The study shows evidence, for the first time, of the foetal exposure to gluten immunogenic peptides and establishes a positive correlation with maternal gluten intake. The results obtained point to a novel physiological concept as they describe a plausible closed-loop circuit entailing foetal swallowing of GIP contained in AF and its subsequent excretion through the foetal kidneys. The study adds important new information to understanding the coeliac exposome. |
Agencias financiadoras | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Junta de Andalucía Federación de Asociaciones de Celíacos de España (FACE) |
Identificador del proyecto | US-15332
SUBN/2019/005 |
Cita | Moreno Amador, M.d.L., González Rovira, M., Martínez Pancorbo, C., Martín Cameán, M., Najar Moyano, A.M., Romero, M.,...,Sousa Martín, C. (2024). Foetal gluten immunogenic peptides during pregnancy: a new determinant on the coeliac exposome.. BMC Medicine, 22 (1), 295. https://doi.org/10.1186/s12916-024-03495-9. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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s12916-024-03495-9.pdf | 1.906Mb | [PDF] | Ver/ | |
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