Article
Divergent approach to nanoscale glycomicelles and photo-responsive supramolecular glycogels. Implications for drug delivery and photoswitching lectin affinity
Author/s | Romero Ben, Elena
Castillejos Anguiano, María del Carmen Rosales Barrios, Cristian Expósito, María Ruda, Pilar Castillo, Paula M. Khiar, Noureddine |
Department | Universidad de Sevilla. Departamento de Química orgánica |
Publication Date | 2023-10-09 |
Deposit Date | 2024-06-11 |
Published in |
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Abstract | The field of stimuli-responsive supramolecular biomaterials has rapidly advanced in recent years, with potential applications in diverse areas such as cancer theranostics, tissue engineering, and catalysis. However, designing ... The field of stimuli-responsive supramolecular biomaterials has rapidly advanced in recent years, with potential applications in diverse areas such as cancer theranostics, tissue engineering, and catalysis. However, designing molecular materials that exhibit predetermined hierarchical self-assembly to control the size, morphology, surface chemistry, and responsiveness of the final nanostructures remains a significant challenge. In this study, we present a divergent synthetic approach for the fabrication of spherical micelles and functional 1D-glyconanotube-based photoresponsive gels from structurally related diazobenzene/diacetylene glycolipids. The resulting nanostructures were characterized using NMR, TEM, and SEM, confirming the formation of spherical and tubular nanostructures in both the gel and solution states. Upon UV irradiation, a reversible gel–sol transition was observed, resulting from the photoswitching of the azobenzene unit from the stretched trans form to the compact, metastable cis form. Our gels were shown to enable spatio-temporal control of the adhesion and release of the lectin Concanavalin A, demonstrating potential use as regenerable biomaterials to fight against infections with toxins and pathogens. Additionally, our micelles and gels were evaluated as nanocontainers for loading and controlled release of hydrophobic dyes and antitumoural agents, suggesting their possible use as smart theranostic drug delivery systems. |
Funding agencies | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) European Commission. Fondo Social Europeo (FSO) Consejo Superior de Investigaciones Científicas (CSIC) Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI) |
Project ID. | PID2020-119949RB-I00/AEI/ 10.13039/501100011033
PY20_00882 y CV20-04221 CSIC-COV19-047 FQM-313 |
Citation | Romero Ben, E., Castillejos Anguiano, M.d.C., Rosales Barrios, C., Expósito, M., Ruda, P., Castillo, P.M. y Khiar, N. (2023). Divergent approach to nanoscale glycomicelles and photo-responsive supramolecular glycogels. Implications for drug delivery and photoswitching lectin affinity. Journal of Materials Chemistry B, 11 (42), 10189-10205. https://doi.org/10.1039/D3TB01713C. |
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