Article
Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications
Author/s | Sánchez Cid, Pablo
Gónzalez-Ulloa, Gabriel Alonso González, María Jiménez-Rosado, Mercedes Rafii-El-Idrissi Benhnia, Mohammed Romero García, Alberto Ostos Marcos, Francisco José Pérez-Puyana, Víctor Manuel |
Department | Universidad de Sevilla. Departamento de Ingeniería Química Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Publication Date | 2023-09 |
Deposit Date | 2024-06-05 |
Published in |
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Abstract | Chitosan (CH) is a very well-known biopolymer that has been widely used for the development of biomaterials with a wide range of applications in the biomedical field, such as the preparation of hydrogels, owing to its ... Chitosan (CH) is a very well-known biopolymer that has been widely used for the development of biomaterials with a wide range of applications in the biomedical field, such as the preparation of hydrogels, owing to its outstanding anti-inflammatory, antibacterial and antifungal properties, biocompatibility and biodegradability, although they present limited mechanical properties. Chemical crosslinking is one of the most recurrent strategies for the reinforcement of these structures and, above all, crosslinking with natural-origin compounds that do not compromise their biocompatibility is considered a hot topic in this research field. D-fructose (F), obtained from the hydrolyzation and further isomerization of starch, an abundant raw material and genipin (G), which is extracted from the fruits of Gardenia jasminoides Ellis are used as natural crosslinkers. Chitosan-based hydrogels crosslinked with each crosslinking agent are prepared and characterized through Fourier transform infrared (FTIR) spectroscopy, crosslinking and swelling degree determination, rheological, microstructural, and biological studies. The results demonstrate that crosslinking with G is more beneficial for chitosan-based hydrogels since these samples showed more compact structures and better rheological performance. Additionally, excellent biological in vitro behavior due to the crosslinking with G, unlike that of F. |
Funding agencies | Ministerio de Ciencia e Innovación (MICIN). España European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Junta de Andalucía European Commission. Fondo Social Europeo (FSO) |
Project ID. | PID2021-124294OB-C21
PAIDI DOCTOR 2019–2020 DOC_00586 PAIDI DOCTOR 2019–2020 DOC_00963 |
Citation | Sánchez Cid, P., Gónzalez-Ulloa, G., Alonso González, M., Jiménez-Rosado, M., Rafii-El-Idrissi Benhnia, M., Romero García, A.,...,Pérez-Puyana, V.M. (2023). Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications. Macromolecular Materials and Engineering, 308 (12), 2300195. https://doi.org/10.1002/mame.202300195. |
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