Artículo
Chitosan-silica hybrid biomaterials for bone tissue engineering: a comparative study of xerogels and aerogels
Autor/es | Pérez Moreno, Antonio
Piñero, Manuel Fernández Montesinos, Rafael Pinaglia Tobaruela, Gonzalo Reyes Peces, María V. Mesa Díaz, María del Mar Esquivias Fedriani, Luis María Salido, Mercedes |
Departamento | Universidad de Sevilla. Departamento de Física de la Materia Condensada |
Fecha de publicación | 2023-05-05 |
Fecha de depósito | 2024-06-04 |
Publicado en |
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Resumen | Chitosan (CS) is a natural biopolymer that shows promise as a biomaterial for bone-tissue regeneration. However, because of their limited ability to induce cell differentiation and high degradation rate, among other drawbacks ... Chitosan (CS) is a natural biopolymer that shows promise as a biomaterial for bone-tissue regeneration. However, because of their limited ability to induce cell differentiation and high degradation rate, among other drawbacks associated with its use, the creation of CS-based biomaterials remains a problem in bone tissue engineering research. Here we aimed to reduce these disadvantages while retaining the benefits of potential CS biomaterial by combining it with silica to provide sufficient additional structural support for bone regeneration. In this work, CS-silica xerogel and aerogel hybrids with 8 wt.% CS content, designated SCS8X and SCS8A, respectively, were prepared by sol-gel method, either by direct solvent evaporation at the atmospheric pressure or by supercritical drying in CO2, respectively. As reported in previous studies, it was confirmed that both types of mesoporous materials exhibited large surface areas (821 m2g−1–858 m2g−1) and outstanding bioactivity, as well as osteoconductive properties. In addition to silica and chitosan, the inclusion of 10 wt.% of tricalcium phosphate (TCP), designated SCS8T10X, was also considered, which stimulates a fast bioactive response of the xerogel surface. The results here obtained also demonstrate that xerogels induced earlier cell differentiation than the aerogels with identical composition. In conclusion, our study shows that the sol-gel synthesis of CS-silica xerogels and aerogels enhances not only their bioactive response, but also osteoconduction and cell differentiation properties. Therefore, these new biomaterials should provide adequate secretion of the osteoid for a fast bone regeneration. |
Agencias financiadoras | Junta de Andalucía European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | CTS 253
PI 013/017 18_106598 |
Cita | Pérez Moreno, A., Piñero, M., Fernández Montesinos, R., Pinaglia Tobaruela, G., Reyes Peces, M.V., Mesa Díaz, M.d.M.,...,Salido, M. (2023). Chitosan-silica hybrid biomaterials for bone tissue engineering: a comparative study of xerogels and aerogels. Gels, 9 (5), 383. https://doi.org/10.3390/gels9050383. |
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