Article
The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study)
Author/s | Martín Sierra, Carmen
José Bravo, María Sáez, María E. de Rojas, Itziar Santos, Marta Martín Carmona, Jesica González-Serna Martín, Manuel Alejandro ![]() ![]() ![]() ![]() ![]() ![]() ![]() Pineda Vergara, Juan Antonio ![]() ![]() ![]() ![]() ![]() ![]() Macías Sánchez, Juan ![]() ![]() ![]() ![]() ![]() ![]() Real Navarrete, Luis Miguel ![]() ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Departamento de Fisiología Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología Universidad de Sevilla. Departamento de Medicina |
Publication Date | 2024 |
Deposit Date | 2024-06-03 |
Published in |
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Abstract | Background & aims: It has been reported that specific killer-cell immunoglobulin-like receptors (KIRs) and HLA genotype combinations, such as KIR2DS4/HLA-C1 with presence of KIRDL2 or KIRDL3, homozygous KIRDL3/ HLA-C1 and ... Background & aims: It has been reported that specific killer-cell immunoglobulin-like receptors (KIRs) and HLA genotype combinations, such as KIR2DS4/HLA-C1 with presence of KIRDL2 or KIRDL3, homozygous KIRDL3/ HLA-C1 and KIR3DL1/≥2HLA-Bw4, are strongly associated with the lack of active infection and seroconversion after exposition to hepatitis C virus (HCV). Objective: To determine whether these KIR-HLA combinations are relevant factors involved in that phenotype. Patients and methods: In this retrospective case-control study, genotype data from a genome-wide association study previously performed on low susceptibility to HCV-infection carried out on 27 high-risk HCV-eronegative (HRSN) individuals and 743 chronically infected (CI) subjects were used. HLA alleles were imputed using R package HIBAG v1.2223 and KIR genotypes were imputed using the online resource KIR*IMP v1.2.0. Results: It was possible to successfully impute at least one KIR-HLA genotype combination previously associated with the lack of infection and seroconversion after exposition to HCV in a total of 23 (85.2%) HRSN individuals and in 650 (87.5%) CI subjects. No KIR-HLA genotype combination analyzed was related to the HRSN condition. Conclusions: Our results suggest that those KIR-HLA genotype combinations are not relevant factors involved in the lack of infection and seroconversion after exposition to HCV. More studies will be needed to completely understand this phenotype. |
Funding agencies | Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica Junta de Andalucía CIBERINFEC Instituto de Salud Carlos III Ministerio de Ciencia e Innovación (MICIN). España European Union (UE) |
Project ID. | GEHEP-012
![]() PI-0001/2017 ![]() CB21/13/00118 ![]() B-0061- 2021 ![]() CM21/00263 ![]() |
Citation | Martín Sierra, C., José Bravo, M., Sáez, M.E., de Rojas, I., Santos, M., Martín Carmona, J.,...,Real Navarrete, L.M. (2024). The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study). Antiviral Research, 222, 105795. https://doi.org/10.1016/j.antiviral.2024.105795. |
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