Artículo
Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial
Autor/es | Pérez Simón, José Antonio
López-Villar, Olga Andreu, Enrique J. Rifón, José Muntion, Sandra Campelo, María Diez Sánchez-Guijo, Fermín Martinez, Carmen Valcarcel, David Del Cañizo, Consuelo |
Departamento | Universidad de Sevilla. Departamento de Medicina Instituto de Biomedicina de Sevilla (IBIS) |
Fecha de publicación | 2011 |
Fecha de depósito | 2024-05-06 |
Publicado en |
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Resumen | This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human
serum for the treatment of refractory acute or chronic graftversus-host disease. Twenty-eight expansions ... This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum for the treatment of refractory acute or chronic graftversus-host disease. Twenty-eight expansions were started. In 22, a minimum of more than 1x106 mesenchymal stem cells/kg were obtained after a median of 26 days; this threshold was not obtained in the remaining cases. Ten patients received cells for the treatment of refractory or relapsed acute graft-versus-host disease and 8 for chronic disease. One patient treated for acute graft-versus-host disease obtained a complete response, 6 had a partial response and 3 did not respond. One of the chronic patients achieved complete remision, 3 a partial response, and 4 did not respond. The current study supports the use of this approach in less heavily treated patients for both acute and chronic graft-versus-host disease. |
Cita | Pérez Simón, J.A., López-Villar, O., Andreu, E.J., Rifón, J., Muntion, S., Campelo, M.D.,...,Del Cañizo, C. (2011). Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial. Haematologica, 96 (7), 1072-1076. https://doi.org/10.3324/haematol.2010.038356. |
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