Artículo
Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications
Autor/es | Medrano, Mayte
Carrillo-Cruz, Estrella Montero, Isabel Pérez Simón, José Antonio |
Departamento | Universidad de Sevilla. Departamento de Medicina Instituto de Biomedicina de Sevilla (IBIS) |
Fecha de publicación | 2018-09-08 |
Fecha de depósito | 2024-05-06 |
Publicado en |
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Resumen | Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR).
It plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display
other important effects called ... Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display other important effects called “non-classical actions.” Among them, vitamin D regulates immune cells function and hematopoietic cells differentiation and proliferation. Based on these effects, it is currently being evaluated for the treatment of hematologic malignancies. In addition, vitamin D levels have been correlated with patients’ outcome after allogeneic stem cell transplantation, where it might regulate immune response and, accordingly, might influence the risk of graft-versus-host disease. Here, we present recent advances regarding its clinical applications both in the treatment of hematologic malignancies and in the transplant setting. |
Agencias financiadoras | Instituto de Carlos III-FEDER |
Identificador del proyecto | PI17/02177 |
Cita | Medrano, M., Carrillo-Cruz, E., Montero, I. y Pérez Simón, J.A. (2018). Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. International Journal of Molecular Sciences, 19 (9), 2663. https://doi.org/10.3390/ijms19092663. |
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