Artículo
Accumulation and Metabolization of the Antidepressant Venlafaxine and its Main Metabolite o-desmethylvenlafaxine in non-target Marine Organisms Holothuria Tubulosa, Anemonia Sulcata and Actinia Equina
Autor/es | Gómez-Regalado, María del Carmen
Martín Bueno, Julia Hidalgo, Félix Santos Morcillo, Juan Luis Aparicio Gómez, Irene Alonso Álvarez, Esteban Zafra Gómez, Alberto |
Departamento | Universidad de Sevilla. Departamento de Química Analítica |
Fecha de publicación | 2023 |
Fecha de depósito | 2024-04-08 |
Publicado en |
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Resumen | The assessment of exposure to the antidepressant venlafaxine and its major metabolite o-desmethylvenlafaxine in Holothuria tubulosa, Anemonia sulcata and Actinia equina is proposed. A 28-day exposure experiment (10 μg/L ... The assessment of exposure to the antidepressant venlafaxine and its major metabolite o-desmethylvenlafaxine in Holothuria tubulosa, Anemonia sulcata and Actinia equina is proposed. A 28-day exposure experiment (10 μg/L day) followed by a 52-day depuration period was conducted. The accumulation shows a first-order kinetic process reaching an average concentration of 49,125/54342 ng/g dw in H. tubulosa and 64,810/93007 ng/g dw in A. sulcata. Venlafaxine is considered cumulative (BCF > 2000 L/kg dw) in H. tubulosa, A. sulcata and A. equina respectively; and o–desmethylvenlafaxine in A. sulcata. Organism-specific BCF generally followed the order A. sulcata > A. equina > H. tubulosa. The study revealed differences between tissues in metabolizing abilities in H. tubulosa this effect increases significantly with time in the digestive tract while it was negligible in the body wall. The results provide a description of venlafaxine and o-desmethylvenlafaxine accumulation in common and non-target organisms in the marine environment. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía |
Identificador del proyecto | PID2020-117641RB-I0
B.RNM.362.UGR20 P20_00556 |
Cita | Gómez-Regalado, M.d.C., Martín Bueno, J., Hidalgo, F., Santos Morcillo, J.L., Aparicio Gómez, I., Alonso Álvarez, E. y Zafra Gómez, A. (2023). Accumulation and Metabolization of the Antidepressant Venlafaxine and its Main Metabolite o-desmethylvenlafaxine in non-target Marine Organisms Holothuria Tubulosa, Anemonia Sulcata and Actinia Equina. Marine Pollution Bulletin, 192, 115055. https://doi.org/10.1016/j.marpolbul.2023.115055. |
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