dc.creator | Alfaro Lara, Verónica Inmaculada | es |
dc.creator | Muñoz Hernández, Rocío | es |
dc.creator | Giménez Miranda, Luis | es |
dc.creator | Beltrán Romero, Luis Matías | es |
dc.creator | Castell Montsalve, Francisco Javier | es |
dc.creator | Stiefel García-Junco, Pablo Enrique | es |
dc.date.accessioned | 2024-04-08T10:58:30Z | |
dc.date.available | 2024-04-08T10:58:30Z | |
dc.date.issued | 2022-10-16 | |
dc.identifier.citation | Alfaro Lara, V.I., Muñoz Hernández, R., Giménez Miranda, L., Beltrán Romero, L.M., Castell Montsalve, F.J. y Stiefel García-Junco, P.E. (2022). Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients. Journal of Clinical Hypertension, 25 (1), 38-46. https://doi.org/10.1111/jch.14600. | |
dc.identifier.issn | 1751-7176 | es |
dc.identifier.uri | https://hdl.handle.net/11441/156709 | |
dc.description.abstract | Thepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction andplateletorendothelialcelldestruction.Theauthorsstudiedagroupof40malehyper-tensivepatientswithwell-controlledbloodpressure,maintainingastableweight,andhavingnotchangedtheirmedicationduringthelastyear.Pancreasfatcontentwascor-relatedwithHOMA-IR(r=.616,p<.001),HOMA-S(r=−.439,p<.005),betacellfunctionparameter(r=.457,p<.005),andQUICKI(r=.412,p<.01),whereasliverfatwasnotpatientsinthehighestquartileofpancreasfatcontenthadmorecirculatingendothelialmicroparticlesthanpatientsintheotherquartiles(median129[94.3–200]vs.60.9[49.4–88.8],p=.002).However,patientsinthehighestquartileofthepancreasfat content distribution did not differ from the lowest in hyperemic response afterischemianorcirculatingplateletmicroparticlescount.Liverfatcontentwasnotrelatedto any of the parameters studied. In a multivariate stepwise binary logistic regres-sionanalysis(WaldMethod)circulatingendothelialmicroparticlesremainsignificantlyassociatedwithpancreasfatcontentafteradjustingforconfoundingfactors,suchastobacco,diabetesmellitus,hypercholesterolemia,ormetabolicsyndrome.Ourresultsreflectthatinessentialhypertension,pancreasfatcontentissuperiortoliverfattostudybeta-cellfunctionalityandinsulinresistance.Moreover,theauthorsdescribedforthefirsttimethatpancreasfatcontentisrelatedtoendothelialcelldestruction.Furtherstudiesareneededtoconfirmthispoint. | es |
dc.description.sponsorship | Instituto de Salud Carlos III PI13/01917 | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language.iso | eng | es |
dc.publisher | Wiley Open Access | es |
dc.relation.ispartof | Journal of Clinical Hypertension, 25 (1), 38-46. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | endothelialdysfunction | es |
dc.subject | endothelialmicroparticle | es |
dc.subject | HOMA | es |
dc.subject | pancreasfatcontent | es |
dc.subject | QUICKI | es |
dc.title | Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.projectID | PI13/01917 | es |
dc.relation.publisherversion | https://doi.org/10.1111/jch.14600 | es |
dc.identifier.doi | 10.1111/jch.14600 | es |
dc.journaltitle | Journal of Clinical Hypertension | es |
dc.publication.volumen | 25 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 38 | es |
dc.publication.endPage | 46 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |