Article
Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
Author/s | Alfaro Lara, Verónica Inmaculada
Muñoz Hernández, Rocío ![]() ![]() ![]() ![]() ![]() ![]() Giménez Miranda, Luis Beltrán Romero, Luis Matías ![]() ![]() ![]() ![]() ![]() ![]() ![]() Castell Montsalve, Francisco Javier Stiefel García-Junco, Pablo Enrique ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Departamento de Fisiología |
Publication Date | 2022-10-16 |
Deposit Date | 2024-04-08 |
Published in |
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Abstract | Thepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction ... Thepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction andplateletorendothelialcelldestruction.Theauthorsstudiedagroupof40malehyper-tensivepatientswithwell-controlledbloodpressure,maintainingastableweight,andhavingnotchangedtheirmedicationduringthelastyear.Pancreasfatcontentwascor-relatedwithHOMA-IR(r=.616,p<.001),HOMA-S(r=−.439,p<.005),betacellfunctionparameter(r=.457,p<.005),andQUICKI(r=.412,p<.01),whereasliverfatwasnotpatientsinthehighestquartileofpancreasfatcontenthadmorecirculatingendothelialmicroparticlesthanpatientsintheotherquartiles(median129[94.3–200]vs.60.9[49.4–88.8],p=.002).However,patientsinthehighestquartileofthepancreasfat content distribution did not differ from the lowest in hyperemic response afterischemianorcirculatingplateletmicroparticlescount.Liverfatcontentwasnotrelatedto any of the parameters studied. In a multivariate stepwise binary logistic regres-sionanalysis(WaldMethod)circulatingendothelialmicroparticlesremainsignificantlyassociatedwithpancreasfatcontentafteradjustingforconfoundingfactors,suchastobacco,diabetesmellitus,hypercholesterolemia,ormetabolicsyndrome.Ourresultsreflectthatinessentialhypertension,pancreasfatcontentissuperiortoliverfattostudybeta-cellfunctionalityandinsulinresistance.Moreover,theauthorsdescribedforthefirsttimethatpancreasfatcontentisrelatedtoendothelialcelldestruction.Furtherstudiesareneededtoconfirmthispoint. |
Funding agencies | Instituto de Salud Carlos III |
Project ID. | PI13/01917
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Citation | Alfaro Lara, V.I., Muñoz Hernández, R., Giménez Miranda, L., Beltrán Romero, L.M., Castell Montsalve, F.J. y Stiefel García-Junco, P.E. (2022). Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients. Journal of Clinical Hypertension, 25 (1), 38-46. https://doi.org/10.1111/jch.14600. |
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