Artículo
Deep Eutectic Solvents as Catalysts in the Synthesis of Active Pharmaceutical Ingredients and Precursors
Título alternativo | Deep Eutectic Solvents as Catalysts in the Synthesis of Active Pharmaceutical Ingredients and Precursors |
Autor/es | Falcini, Chiara
Gonzalo Calvo, Gonzalo de |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2024-02-02 |
Fecha de depósito | 2024-04-01 |
Publicado en |
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Resumen | Deep Eutectic Solvents (DESs) have appeared in recent years as an appealing alternative to classical organic solvents, due to their valuable environmental properties. In addition, these compounds, formed by the combination ... Deep Eutectic Solvents (DESs) have appeared in recent years as an appealing alternative to classical organic solvents, due to their valuable environmental properties. In addition, these compounds, formed by the combination of one hydrogen bond donor with a hydrogen bond acceptor at a defined stoichiometric ratio, present other valuable activities not only as a reaction medium. DESs can also be employed as catalysts through hydrogen-bond interactions in different chemical transformations, thus substituting hazardous reagents and solvents. The search for novel and more environmentally friendly catalysts is an area of interest of pharmaceutical chemists, and therefore, the efforts made in the application of DESs as catalysts in the synthesis of APIs or its precursors are described, focusing mainly on condensations, nucleophilic additions to carbonyl moieties, and multicomponent reactions. |
Agencias financiadoras | European Union (UE) |
Identificador del proyecto | 101072731 |
Cita | Falcini, C. y Gonzalo Calvo, G.d. (2024). Deep Eutectic Solvents as Catalysts in the Synthesis of Active Pharmaceutical Ingredients and Precursors. Catalysts, 165, 175-183. https://doi.org/10.3390/catal14020120. |
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catalysts-14-00120.pdf | 3.529Mb | [PDF] | Ver/ | |