dc.creator | Silva-Hucha, Silvia | es |
dc.creator | Fernandez de Sevilla, Estrella M. | es |
dc.creator | Humphreys, Kirsty M. | es |
dc.creator | Benson, Fiona E. | es |
dc.creator | Franco, Jaime M. | es |
dc.creator | Pozo Pérez, David | es |
dc.creator | Pastor Loro, Ángel Manuel | es |
dc.creator | Morcuende Fernández, Sara R. | es |
dc.date.accessioned | 2024-03-13T14:10:15Z | |
dc.date.available | 2024-03-13T14:10:15Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Silva-Hucha, S., Fern andez de Sevilla, E.M., Humphreys, .M., Benson, F.E., Franco, J.M., Pozo Pérez, D.,...,Morcuende, S. (2024). VEGF expression disparities in brainstem motor neurons of the SOD1G93A ALS model: Correlations with neuronal vulnerability. Neurotherapeutics. https://doi.org/10.1016/j.neurot.2024.e00340. | |
dc.identifier.issn | 1878-7479 | es |
dc.identifier.uri | https://hdl.handle.net/11441/156220 | |
dc.description.abstract | Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by severe muscle weakness
mainly due to degeneration and death of motor neurons. A peculiarity of the neurodegenerative processes is the
variable susceptibility among distinct neuronal populations, exemplified by the contrasting resilience of motor
neurons innervating the ocular motor system and the more vulnerable facial and hypoglossal motor neurons. The
crucial role of vascular endothelial growth factor (VEGF) as a neuroprotective factor in the nervous system is wellestablished since a deficit of VEGF has been related to motoneuronal degeneration. In this study, we investigated
the survival of ocular, facial, and hypoglossal motor neurons utilizing the murine SOD1G93A ALS model at various
stages of the disease. Our primary objective was to determine whether the survival of the different brainstem
motor neurons was linked to disparate VEGF expression levels in resilient and susceptible motor neurons
throughout neurodegeneration. Our findings revealed a selective loss of motor neurons exclusively within the
vulnerable nuclei. Furthermore, a significantly higher level of VEGF was detected in the more resistant motor
neurons, the extraocular ones. We also examined whether TDP-43 dynamics in the brainstem motor neuron of
SOD mice was altered. Our data suggests that the increased VEGF levels observed in extraocular motor neurons
may potentially underlie their resistance during the neurodegenerative processes in ALS in a TDP-43-independent
manner. Our work might help to better understand the underlying mechanisms of selective vulnerability of motor
neurons in ALS. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Neurotherapeutics | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | ALS | es |
dc.subject | SOD1G93A | es |
dc.subject | Brainstem motor neurons | es |
dc.subject | VEGF | es |
dc.subject | TDP-43 | es |
dc.subject | Extraocular system | es |
dc.title | VEGF expression disparities in brainstem motor neurons of the SOD1GP3A ALS model: Correlations with neuronal vulnerability | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1878747924000266?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.neurot.2024.e00340 | es |
dc.journaltitle | Neurotherapeutics | es |
dc.publication.initialPage | e00340 | |