dc.creator | Rivero-Pino, Fernando | es |
dc.creator | Villanueva, Álvaro | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | Sánchez Fidalgo, Susana | es |
dc.creator | Millán Linares, María C. | es |
dc.date.accessioned | 2024-02-21T18:36:54Z | |
dc.date.available | 2024-02-21T18:36:54Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Rivero-Pino, F., Villanueva, Á., Montserrat de la Paz, S., Sánchez Fidalgo, S. y Millán Linares, M.C. (2023). Evidence of Immunomodulatory Food-Protein Derived Peptides in Human Nutritional Interventions: Review on the Outcomes and Potential Limitations. Nutrients, 15 (12), 2681. https://doi.org/10.3390/nu15122681. | |
dc.identifier.issn | 2072-6643 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155443 | |
dc.description.abstract | The immune system is somehow related to all the metabolic pathways, in a bidirectional
way, and the nutritional interventions affecting these pathways might have a relevant impact on
the inflammatory status of the individuals. Food-derived peptides have been demonstrated to exert
several bioactivities by in vitro or animal studies. Their potential to be used as functional food
is promising, considering the simplicity of their production and the high value of the products
obtained. However, the number of human studies performed until now to demonstrate effects
in vivo is still scarce. Several factors must be taken into consideration to carry out a high-quality
human study to demonstrate immunomodulatory-promoting properties of a test item. This review
aims to summarize the recent human studies published in which the purpose was to demonstrate
bioactivity of protein hydrolysates, highlighting the main results and the limitations that can restrict
the relevance of the studies. Results collected are promising, although in some studies, physiological
changes could not be observed. When responses were observed, they sometimes did not refer to
relevant parameters and the immunomodulatory properties could not be clearly established with
the current evidence. Well-designed clinical trials are needed in order to evaluate the role of protein
hydrolysates in immunonutrition. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | Mdpi | es |
dc.relation.ispartof | Nutrients, 15 (12), 2681. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Antidiabetic | es |
dc.subject | Antioxidant | es |
dc.subject | Clinical trial | es |
dc.subject | Cytokines | es |
dc.subject | Inflammation | es |
dc.subject | Immune system | es |
dc.subject | Protein hydrolysate | es |
dc.subject | Validation study | es |
dc.title | Evidence of Immunomodulatory Food-Protein Derived Peptides in Human Nutritional Interventions: Review on the Outcomes and Potential Limitations | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/15/12/2681 | es |
dc.identifier.doi | 10.3390/nu15122681 | es |
dc.journaltitle | Nutrients | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 2681 | es |