Article
Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells
Author/s | Morales, Fátima
![]() ![]() ![]() ![]() ![]() ![]() ![]() Ramirez, A. Morata-Tarifa, C. Navarro, S.A. Marchal, J.A. Campos, J.M. Conejo-Garcia, A. |
Director | |
Department | Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública |
Publication Date | 2017 |
Deposit Date | 2024-02-20 |
Published in |
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Abstract | Cancer is among the leading causes of death worldwide. Medical interest has focused on macrocyclic polyamines because of their properties as antitumor agents. Results/Methodology: We have designed and synthesized a series ... Cancer is among the leading causes of death worldwide. Medical interest has focused on macrocyclic polyamines because of their properties as antitumor agents. Results/Methodology: We have designed and synthesized a series of 1,2-diaminocyclohexane derivatives with notable in vitro antiproliferative activities against the MCF-7, HCT-116 and A375 cancer cell lines. Cell cycle and apoptosis analyses were also carried out. Our results show that all the compounds are potent cytotoxic agents, especially against the A375 cell line. Conclusion: The selective activity of the macrocyclic derivative against A375, via apoptosis, supposes a great advantage for future therapeutic use. This exemplifies the potential of 1,2-diaminocyclohexane derivatives to qualify as lead structures for future anticancer drug development due to their easy syntheses and noteworthy bioactivity. |
Funding agencies | Instituto Carlos III |
Project ID. | PI10/00592
![]() PI10/02295 ![]() |
Citation | Morales, F., Ramirez, A., Morata-Tarifa, C., Navarro, S.A., Marchal, J.A., Campos, J.M. y Conejo-Garcia, A. (2017). Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells. Future Meidicinal Chemistry, 9 (3), 293-302. https://doi.org/10.4155/fmc-2016-0212. |
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