Artículo
Bioavailability and provitamin A activity of neurosporaxanthin in mice
Autor/es | Miller, Anthony P
Hornero-Mendez, Damaso Bandara, Sepalika Parra-Rivero, Obdulia Limón Mirón, María del Carmen Von Lintig, Johannes Ávalos Cordero, Francisco Javier Amengual, Jaume |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2023-10-20 |
Fecha de depósito | 2024-02-12 |
Publicado en |
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Resumen | Various species of ascomycete fungi synthesize the carboxylic carotenoid neurosporaxanthin. The unique chemical structure of this xanthophyll reveals that: (1) Its carboxylic end and shorter length increase the polarity ... Various species of ascomycete fungi synthesize the carboxylic carotenoid neurosporaxanthin. The unique chemical structure of this xanthophyll reveals that: (1) Its carboxylic end and shorter length increase the polarity of neurosporaxanthin in comparison to other carotenoids, and (2) it contains an unsubstituted β-ionone ring, conferring the potential to form vitamin A. Previously, neurosporaxanthin production was optimized in Fusarium fujikuroi, which allowed us to characterize its antioxidant properties in in vitro assays. In this study, we assessed the bioavailability of neurosporaxanthin compared to other provitamin A carotenoids in mice and examined whether it can be cleaved by the two carotenoid-cleaving enzymes: β-carotene-oxygenase 1 (BCO1) and 2 (BCO2). Using Bco1−/−Bco2−/− mice, we report that neurosporaxanthin displays greater bioavailability than β-carotene and β-cryptoxanthin, as evidenced by higher accumulation and decreased fecal elimination. Enzymatic assays with purified BCO1 and BCO2, together with feeding studies in wild-type, Bco1−/−, Bco2−/−, and Bco1−/−Bco2−/− mice, revealed that neurosporaxanthin is a substrate for either carotenoid-cleaving enzyme. Wild-type mice fed neurosporaxanthin displayed comparable amounts of vitamin A to those fed β-carotene. Together, our study unveils neurosporaxanthin as a highly bioavailable fungal carotenoid with provitamin A activity, highlighting its potential as a novel food additive. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Agencia Estatal de Investigación. España Junta de Andalucía National Institutes of Health. United States Department of Agriculture. United States |
Identificador del proyecto | 2018-101902-B-I00
2015-69613-R RED2022-134577-T P10-CTS-6638 P20-01243 HL147252 W5002 |
Cita | Miller, A.P., Hornero-Mendez, D., Bandara, S., Parra-Rivero, O., Limón Mirón, M.d.C., Von Lintig, J.,...,Amengual, J. (2023). Bioavailability and provitamin A activity of neurosporaxanthin in mice. Communications Biology, 6 (1), 1068. https://doi.org/10.1038/s42003-023-05446-1. |
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