Article
Sex-specific differences in intestinal microbiota associated with cardiovascular diseases
Author/s | García Fernández, Helena
Arenas de Larriva, Antonio Pablo López Moreno, Javier Gutiérrez Mariscal, Francisco Miguel Romero Cabrera, Juan Luis Molina Abril, Helena ![]() ![]() ![]() ![]() ![]() ![]() ![]() Torres Peña, José David Rodríguez Cano, Diego Malagón Poyato, María del Mar Ordovás Muñoz, José María Delgado Lista, Javier Pérez Martínez, Pablo López Miranda, José Camargo García, Antonio |
Department | Universidad de Sevilla. Departamento de Matemática Aplicada I (ETSII) |
Publication Date | 2024-01-19 |
Deposit Date | 2024-02-09 |
Published in |
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Abstract | Background Cardiovascular diseases (CVD), including coronary heart disease (CHD), display a higher prevalence
in men than women. This study aims to evaluate the variations in the intestinal microbiota between men and ... Background Cardiovascular diseases (CVD), including coronary heart disease (CHD), display a higher prevalence in men than women. This study aims to evaluate the variations in the intestinal microbiota between men and women aficted with CHD and delineate these against a non-CVD control group for each sex. Methods Our research was conducted in the framework of the CORDIOPREV study, a clinical trial which involved 837 men and 165 women with CHD. We contrasted our fndings with a reference group of 375 individuals (270 men, 105 women) without CVD. The intestinal microbiota was examined through 16S metagenomics on the Illumina MiSeq platform and the data processed with Quiime2 software. Results Our results showed a sex-specifc variation (beta diversity) in the intestinal microbiota, while alpha-biodiver‑ sity remained consistent across both sexes. Linear discriminant analysis efect size (LEfSe) analysis revealed sex-centric alterations in the intestinal microbiota linked to CVD. Moreover, using random forest (RF) methodology, we identifed seven bacterial taxa—g_UBA1819 (Ruminococcaceae), g_Bilophila, g_Subdoligranulum, g_Phascolarctobacterium, f_Barnesiellaceae, g_Ruminococcus, and an unknown genus from the Ruminococcaceae family (Ruminococcaceae incertae sedis)—as key discriminators between men and women diagnosed with CHD. The same taxa also emerged as critical discriminators between CHD-aficted and non-CVD individuals, when analyzed separately by sex. Conclusion Our fndings suggest a sex-specifc dysbiosis in the intestinal microbiota linked to CHD, potentially con‑ tributing to the sex disparity observed in CVD incidence. |
Funding agencies | Junta de Andalucía |
Project ID. | CP14/00114
![]() CPII19/00007 ![]() C1-00012022 ![]() |
Citation | García Fernández, H., Arenas de Larriva, A.P., López Moreno, J., Gutiérrez Mariscal, F.M., Romero Cabrera, J.L., Molina Abril, H.,...,Camargo García, A. (2024). Sex-specific differences in intestinal microbiota associated with cardiovascular diseases. Biology of Sex Differences, 15 (7). https://doi.org/10.1186/s13293-024-00582-7. |
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