Article
Chronic adult-onset of growth hormone/IGF-I hypersecretion improves cognitive functions and LTP and promotes neuronal differentiation in adult rats
Author/s | Martín Rodríguez, Juan Francisco
Ramos Herrero, Víctor Darío Parras, Gloria G. Flores Martínez, Álvaro Madrazo Atutxa, Ainara Cano, David A. Gruart, Agnès Delgado García, José María Leal Cerro, Alfonso Leal-Campanario, Rocío |
Department | Universidad de Sevilla. Instituto de Biomedicina de Sevilla (IBIS) |
Publication Date | 2020 |
Deposit Date | 2024-02-07 |
Published in |
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Awards | Premio Trimestral Publicación Científica Destacada de la US. Facultad de Psicología |
Abstract | Aim
Besides their metabolic and endocrine functions, the growth hormone (GH) and its mediated factor, the insulin-like growth factor I (IGF-I), have been implicated in different brain functions, including neurogenesis. ... Aim Besides their metabolic and endocrine functions, the growth hormone (GH) and its mediated factor, the insulin-like growth factor I (IGF-I), have been implicated in different brain functions, including neurogenesis. Long-lasting elevated GH and IGF-I levels result in non-reversible somatic, endocrine and metabolic morbidities. However, the subcutaneous implantation of the GH-secreting (GH-S) GC cell line in rats leads to the controllable over-secretion of GH and elevated IGF-I levels, allowing the experimental study of their short-term effects on brain functions. Methods Adult rats were implanted with GC cells and checked 10 weeks later, when a GH/IGF-I-secreting tumour was already formed. Results Tumour-bearing rats acquired different operant conditioning tasks faster and better than controls and tumour-resected groups. They also presented better retentions of long-term memories in the passive avoidance test. Experimentally evoked long-term potentiation (LTP) in the hippocampus was also larger and longer lasting in the tumour bearing than in the other groups. Chronic adult-onset of GH/IGF-I hypersecretion caused an acceleration of early progenitors, facilitating a faster neural differentiation, maturation and integration in the dentate gyrus, and increased the complexity of dendritic arbours and spine density of granule neurons. Conclusion Thus, adult-onset hypersecretion of GH/IGF-I improves neurocognitive functions, long-term memories, experimental LTP and neural differentiation, migration and maturation. |
Funding agencies | Ministerio de Economía y Competitividad (MINECO). España Instituto de Salud Carlos III Junta de Andalucía. Consejería de Economía, Innovación, Ciencia y Empleo Junta de Andalucía. Programa Nicolás Monardes |
Project ID. | BFU2014-56692-R
BFU2017-82375-R PI16/00175 BIO122 PI-0302-2012 C-0015-2014 |
Citation | Martín Rodríguez, J.F., Ramos Herrero, V.D., Parras, G.G., Flores Martínez, Á., Madrazo Atutxa, A., Cano, D.A.,...,Leal-Campanario, R. (2020). Chronic adult-onset of growth hormone/IGF-I hypersecretion improves cognitive functions and LTP and promotes neuronal differentiation in adult rats. Acta Physiologica, 229 (2), e13293. https://doi.org/10.1111/apha.13293. |
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