Article
Aberrant cortical associative plasticity associated with severe adult Tourette syndrome
Author/s | Martín Rodríguez, Juan Francisco
![]() ![]() ![]() ![]() ![]() ![]() ![]() Ruiz Rodríguez, María Adilia Palomar, Francisco J. Cáceres Redondo, María Teresa Vargas, Laura Porcacchia, Paolo Gómez-Crespo, Mercedes Huertas-Fernández, Ismael Carrillo, Fátima Madruga-Garrido, Marcos Mir Rivera, Pablo ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Instituto de Biomedicina de Sevilla (IBIS) Univesidad de Sevilla. Departamento de Medicina |
Publication Date | 2015 |
Deposit Date | 2024-02-07 |
Published in |
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Abstract | Background. Recent studies have shown altered cortical plasticity in adult patients with Tourette syndrome. However, the clinical significance of this finding remains elusive. Methods. Motor cortical plasticity was evaluated ... Background. Recent studies have shown altered cortical plasticity in adult patients with Tourette syndrome. However, the clinical significance of this finding remains elusive. Methods. Motor cortical plasticity was evaluated in 15 adult patients with severe Tourette syndrome and 16 healthy controls using the paired associative stimulation protocol by transcranial magnetic stimulation. Associations between paired associative stimulation–induced plasticity and relevant clinical variables, including cortical excitability, psychiatric comorbidities, drug treatment and tic severity, were assessed. Results. Motor cortical plasticity was abnormally increased in patients with Tourette syndrome compared with healthy subjects. This abnormal plasticity was independently associated with tic severity. Conclusion Patients with severe Tourette syndrome display abnormally increased cortical associative plasticity. This aberrant cortical plasticity was associated with tic severity, suggesting an underlying mechanism for tic pathophysiology |
Funding agencies | Junta de Andalucía Ministerio de Economía y Competitividad (MINECO). España Instituto de Salud Carlos III Sociedad Andaluza de Neurología Fundación Alicia Koplowitz Fundación Mutua Madrileña Jacques and Gloria Gossweiler Foundation |
Project ID. | CVI-02526
![]() CGTS-7685 ![]() PI-0377/2007 ![]() PI-0741/2010 ![]() PI-0437-2012 ![]() SAF2007-60700 ![]() PI10/01674 ![]() CP08/00174 ![]() |
Citation | Martín Rodríguez, J.F., Ruiz Rodríguez, M.A., Palomar, F.J., Cáceres Redondo, M.T., Vargas, L., Porcacchia, P.,...,Mir Rivera, P. (2015). Aberrant cortical associative plasticity associated with severe adult Tourette syndrome. Movement Disorders, 30 (3), 431-435. https://doi.org/10.1002/mds.26151. |
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