Article
The Emerging Role of Senotherapy in Cancer: A Comprehensive Review
Author/s | Malayaperumal, Sarubala
Marotta, Francesco Kumar, Makalakshmi Murali Somasundaram, Indumathi Ayala Gómez, Antonio Muñoz Pinto, Mario Faustino Banerjee, Antara Pathak, Surajit |
Department | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular |
Publication Date | 2023-07-22 |
Deposit Date | 2024-01-25 |
Published in |
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Abstract | Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. Senotherapy refers to the targeting of senescent cells to restore tissue homeostasis and mitigate ... Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. Senotherapy refers to the targeting of senescent cells to restore tissue homeostasis and mitigate the deleterious effects associated with senescence. Senolytic drugs represent a promising avenue in cancer treatment, with the potential to target and modulate senescent cells to improve patient outcomes. The review highlights the intricate interplay between the senescence-associated secretory phenotype (SASP) and the tumor microenvironment, emphasizing the role of senescent cells in promoting chronic inflammation, immune evasion, and tumor-cell proliferation. It then explores the potential of senotherapy as a novel strategy for cancer therapy. This review addresses the emerging evidence on the combination of senotherapy with conventional cancer treatments, such as chemotherapy and immunotherapy. |
Citation | Malayaperumal, S., Marotta, F., Kumar, M.M., Somasundaram, I., Ayala Gómez, A., Muñoz Pinto, M.F.,...,The Emerging Role of Senotherapy in Cancer: A Comprehensive Review, (2023). The Emerging Role of Senotherapy in Cancer: A Comprehensive Review. Clinics and Practice, 13 (4), 838-852. https://doi.org/10.3390/clinpract13040076. |
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