Mostrar el registro sencillo del ítem
Artículo
Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension
dc.creator | Moreno Luna, Rafael | es |
dc.creator | Muñoz Hernández, Rocío | es |
dc.creator | Miranda Guisado, María Luisa | es |
dc.creator | Costa, Alzenira F. | es |
dc.creator | Jiménez Jiménez, Luis M. | es |
dc.creator | Vallejo Vaz, Antonio Javier | es |
dc.creator | García Muriana, Francisco José | es |
dc.creator | Villar, José | es |
dc.creator | Stiefel García-Junco, Pablo Enrique | es |
dc.date.accessioned | 2024-01-23T13:22:56Z | |
dc.date.available | 2024-01-23T13:22:56Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Moreno Luna, R., Muñoz Hernández, R., Miranda Guisado, M.L., Costa, A.F., Jiménez Jiménez, L.M., Vallejo Vaz, A.J.,...,Stiefel García-Junco, P.E. (2012). Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. American Journal of Hypertension, 25 (12), 1299-1304. https://doi.org/10.1038/ajh.2012.128. | |
dc.identifier.issn | 1941-7225 | es |
dc.identifier.uri | https://hdl.handle.net/11441/153850 | |
dc.description.abstract | Background: Olive oil polyphenols have been associated with several cardiovascular health benefits. This study aims to examine the influence of a polyphenol-rich olive oil on blood pressure (BP) and endothelial function in 24 young women with high-normal BP or stage 1 essential hypertension. Methods: We conducted a double-blind, randomized, crossover dietary-intervention study. After a run-in period of 4 months (baseline values), two diets were used, one with polyphenol-rich olive oil (∼30 mg/day), the other with polyphenol-free olive oil. Each dietary period lasted 2 months with a 4-week washout between diets. Systolic and diastolic BP, serum or plasma biomarkers of endothelial function, oxidative stress, and inflammation, and ischemia-induced hyperemia in the forearm were measured. Results: When compared to baseline values, only the polyphenol-rich olive oil diet led to a significant (P < 0.01) decrease of 7.91 mm Hg in systolic and 6.65 mm Hg of diastolic BP. A similar finding was found for serum asymmetric dimethylarginine (ADMA) (-0.09 ± 0.01 µmol/l, P < 0.01), oxidized low-density lipoprotein (ox-LDL) (-28.2 ± 28.5 µg/l, P < 0.01), and plasma C-reactive protein (CRP) (-1.9 ± 1.3 mg/l, P < 0.001). The polyphenol-rich olive oil diet also elicited an increase in plasma nitrites/nitrates (+4.7 ± 6.6 µmol/l, P < 0.001) and hyperemic area after ischemia (+345 ± 386 perfusion units (PU)/sec, P < 0.001). Conclusions: We concluded that the consumption of a diet containing polyphenol-rich olive oil can decrease BP and improve endothelial function in young women with high-normal BP or stage 1 essential hypertension. | es |
dc.description.sponsorship | Instituto de Salud Carlos III (RD06/0014/0035) | es |
dc.format | application/pdf | es |
dc.format.extent | 6 p. | es |
dc.language.iso | eng | es |
dc.publisher | Oxford University Press | es |
dc.relation.ispartof | American Journal of Hypertension, 25 (12), 1299-1304. | |
dc.title | Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | RD06/0014/0035 | es |
dc.relation.publisherversion | https://dx.doi.org/10.1038/ajh.2012.128 | es |
dc.identifier.doi | 10.1038/ajh.2012.128 | es |
dc.journaltitle | American Journal of Hypertension | es |
dc.publication.volumen | 25 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 1299 | es |
dc.publication.endPage | 1304 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
10.1038ajh.2012.128.pdf | 535.3Kb | [PDF] | Ver/ | Versión aceptada |
Este registro aparece en las siguientes colecciones
Este documento está protegido por los derechos de propiedad intelectual e industrial. Sin perjuicio de las exenciones legales existentes, queda prohibida su reproducción, distribución, comunicación pública o transformación sin la autorización del titular de los derechos, a menos que se indique lo contrario.