Artículo
Proposed mechanism for regulation of H2O2-induced programmed cell death in plants by binding of cytochrome c to 14-3-3 proteins
Autor/es | Elena-Real, Carlos A.
González Arzola, Katiuska Pérez Mejías, Gonzalo Díaz Quintana, Antonio Jesús Velázquez Campoy, Adrián Desvoyes, Bénédicte Gutiérrez, Crisanto Rosa Acosta, Miguel Ángel de la Díaz Moreno, Irene |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Fecha de publicación | 2021-04 |
Fecha de depósito | 2024-01-16 |
Publicado en |
|
Resumen | Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the double role of extra-mitochondrial cytochrome c in triggering apoptosis and inhibiting survival ... Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the double role of extra-mitochondrial cytochrome c in triggering apoptosis and inhibiting survival pathways is well reported. In plants, however, the specific role of cytochrome c upon release from the mitochondria remains in part veiled yet death stimuli do trigger cytochrome c translocation as well. Here, we identify an Arabidopsis thaliana 14-3-3ι isoform as a cytosolic cytochrome c target and inhibitor of caspase-like activity. This finding establishes the 14-3-3ι protein as a relevant factor at the onset of plant H2O2-induced PCD. The in vivo and in vitro studies herein reported reveal that the interaction between cytochrome c and 14-3-3ι exhibits noticeable similarities with the complex formed by their human orthologues. Further analysis of the heterologous complexes between human and plant cytochrome c with plant 14-3-3ι and human 14-3-3ε isoforms corroborated common features. These results suggest that cytochrome c blocks p14-3-3ι so as to inhibit caspase-like proteases, which in turn promote cell death upon H2O2 treatment. Besides establishing common biochemical features between human and plant PCD, this work sheds light onto the signaling networks of plant cell death. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Ministerio de Ciencia, Innovación y Universidades (MICINN). España Junta de Andalucía |
Identificador del proyecto | BFU2015-71017/BMC
PGC2018-096049-B-I00 RTI2018-094793-B-I00 BIO198 US-1254317 US-1257019 P18-FR-3487 P18-HO-4091 |
Cita | Elena-Real, C.A., González Arzola, K., Pérez Mejías, G., Díaz Quintana, A.J., Velázquez Campoy, A., Desvoyes, B.,...,Díaz Moreno, I. (2021). Proposed mechanism for regulation of H2O2-induced programmed cell death in plants by binding of cytochrome c to 14-3-3 proteins. Plant Journal, 106 (1), 74-85. https://doi.org/10.1111/tpj.15146. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Proposed mechanism.pdf | 1.493Mb | [PDF] | Ver/ | Versión aceptada |