Artículo
Chitosan biofilms: Insights for the selective electromembrane extraction of fluoroquinolones from biological samples
Autor/es | Román Hidalgo, Cristina
Aranda Merino, Noemí López Pérez, Germán Sánchez Coronilla, Antonio Villar Navarro, Mercedes Martín Valero, María Jesús |
Departamento | Universidad de Sevilla. Departamento de Química Analítica Universidad de Sevilla. Departamento de Química Física |
Fecha de publicación | 2021-09-22 |
Fecha de depósito | 2024-01-12 |
Publicado en |
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Premios | Premio Mensual Publicación Científica Destacada de la US. Facultad de Química |
Resumen | A selective electromembrane extraction procedure for the extraction of Enrofloxacin, Marbofloxacin and
Flumequine, usually employed as antibiotic in veterinarian use, is proposed by using a chitosan biofilm,
composed by ... A selective electromembrane extraction procedure for the extraction of Enrofloxacin, Marbofloxacin and Flumequine, usually employed as antibiotic in veterinarian use, is proposed by using a chitosan biofilm, composed by 60% (w/w) chitosan and 40% (w/w) Aliquat®336, as active biopolymeric support. The interaction mechanism occurring between the target drugs and the biopolymer has been deeply studied using the Quantum Theory of Atoms in Molecules. The obtained results show the interaction between the extracted fluoroquinolones and the biomembrane is stabilized by two hydrogen bonds formed between both the carboxyl and keto groups of the drugs with both the amine and hydroxyl groups of glucosamine in the biopolymer. The energetic results agree with the high extraction efficiency obtained for Marbofloxacin, Enrofloxacin and Flumequine in terms of enrichment factors (83, 82 and 58, respectively) in presence of other fluoroquinolones. Under optimum conditions, the proposed electromembrane extraction method exhibits wide linear ranges of 4.2e200 mg L1 , 5.6e200 mg L1 and 5.1e200 mg L1 , respectively; low limits of detection close to 1.3 mg L1 and appropriate repeatability (relative standard deviation values 4e7%). |
Agencias financiadoras | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Ministerio de Ciencia e Innovación (MICIN). España Agencia Estatal de Investigación. España Ministerio de Ciencia, Innovación y Universidades (MICINN). España Junta de Andalucía |
Identificador del proyecto | PGC2018-096608- B-C22
RED2018-102522-T FQM-106 |
Cita | Román Hidalgo, C., Aranda Merino, N., López Pérez, G., Sánchez Coronilla, A., Villar Navarro, M. y Martín Valero, M.J. (2021). Chitosan biofilms: Insights for the selective electromembrane extraction of fluoroquinolones from biological samples. Analytica Chimica Acta, 1179, 338832. https://doi.org/10.1016/j.aca.2021.338832. |
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