Artículo
Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase
Autor/es | Sánchez Aliena
Muñoz Pinto, Mario Faustino Cano Rodríguez, Mercedes |
Departamento | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2022 |
Fecha de depósito | 2024-01-08 |
Publicado en |
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Resumen | Ageing is characterised by the accumulation of molecular and cellular damage through time, leading to a decline in physical and mental abilities. Currently, society has experienced a rapid increase in life expectancy, which ... Ageing is characterised by the accumulation of molecular and cellular damage through time, leading to a decline in physical and mental abilities. Currently, society has experienced a rapid increase in life expectancy, which has led to an increase in age-associated diseases. Therefore, it is crucial to study the process of ageing to guarantee the best conditions in the final stages of life. In recent years, interest has increased in a myokine known as irisin, which is secreted during physical exercise. This polypeptide hormone is produced by various organs, mainly muscle, and once it is released into the blood, it performs a wide variety of functions that are involved in metabolic control and may be relevant during some of the diseases associated with ageing. The aim of this review is to highlight the recent studies of irisin, such as its mechanism of expression, blood release, distribution, tissue target and participation in various cellular metabolic reactions and the relationship with key anti-ageing pathways such as adenosine monophosphate-activated protein kinase, silent information regulator T 1, autophagy and telomerase. In conclusion, irisin is a key player during the ageing process and it could be a novel target molecule for the therapeutic approach to boost longevity pathways. However, more research will be necessary to use this promising hormone for this gain. |
Agencias financiadoras | Junta de Andalucía |
Identificador del proyecto | BIO-158 |
Cita | Sánchez Aliena, , Muñoz Pinto, M.F. y Cano Rodríguez, M. (2022). Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase. Expert reviews in molecular medicine, 25, e4. https://doi.org/10.1017/erm.2022.41. |
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