Article
Selenium, selenoproteins and cancer of the thyroid
Author/s | Rua, Rui Manuel
Nogales Bueno, Fátima Carreras Sánchez, Olimpia Ojeda Murillo, María Luisa |
Department | Universidad de Sevilla. Departamento de Fisiología |
Publication Date | 2023-03 |
Deposit Date | 2023-12-19 |
Published in |
|
Abstract | Selenium is an essential mineral element with important biological functions for the whole body through incorporation into selenoproteins. This element is highly concentrated in the thyroid gland. Selenoproteins provide ... Selenium is an essential mineral element with important biological functions for the whole body through incorporation into selenoproteins. This element is highly concentrated in the thyroid gland. Selenoproteins provide antioxidant protection for this tissue against the oxidative stress caused by free radicals and contribute, via iodothyronine deiodinases, to the metabolism of thyroid hormones. It is known that oxidative stress plays a major role in carcinogenesis and that in recent decades there has been an increase in the incidence of thyroid cancer. The anti-carcinogenic action of selenium, although not fully understood, is mainly attributable to selenoproteins antioxidant properties, and to the ability to modulate cell proliferation (cell cycle and apoptosis), energy metabolism, and cellular immune response, significantly altered during tumorigenesis. Researchers have suggested that different forms of selenium supplementation may be beneficial in the prevention and treatment of thyroid cancer; however, the studies have several methodological limitations. This review is a summary of the current knowledge on how selenium and selenoproteins related to thyroid cancer. |
Funding agencies | Junta de Andalucía |
Project ID. | 2017/CTS-193
2019/CTS-193 |
Citation | Rua, R.M., Nogales Bueno, F., Carreras Sánchez, O. y Ojeda Murillo, M.L. (2023). Selenium, selenoproteins and cancer of the thyroid. Journal of Trace Elements in Medicine and Biology, 76, 127115. https://doi.org/10.1016/j.jtemb.2022.127115. |
Files | Size | Format | View | Description |
---|---|---|---|---|
Selenium selenoproteins.pdf | 746.4Kb | [PDF] | View/ | Versión aceptada |