Article
Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study
Author/s | Babich, Tanya
Naucler, Pontus Valik, John Karlsson Giske, Christian G. Benito, Natividad Cardona, Ruben Rodríguez-Baño, Jesús Cueto López, Marina de Yahav, Dafna |
Department | Universidad de Sevilla. Departamento de Medicina Universidad de Sevilla. Departamento de Microbiología |
Publication Date | 2022 |
Deposit Date | 2023-11-13 |
Published in |
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Abstract | Introduction: There is no consensus regarding
optimal duration of antibiotic therapy for
Pseudomonas aeruginosa bacteremia. We aimed
to evaluate the impact of short antibiotic
course. Methods: We present a retrospective ... Introduction: There is no consensus regarding optimal duration of antibiotic therapy for Pseudomonas aeruginosa bacteremia. We aimed to evaluate the impact of short antibiotic course. Methods: We present a retrospective multicen ter study including patients with P. aeruginosa bacteremia during 2009–2015. We evaluated outcomes of patients treated with short (6–- 10 days) versus long (11–15 days) antibiotic courses. The primary outcome was a composite of 30-day mortality or bacteremia recurrence and/or persistence. Univariate and inverse probability treatment-weighted (IPTW) adjusted multivariate analysis for the primary outcome was performed. To avoid immortal time bias, the landmark method was used. Results: We included 657 patients; 273 received a short antibiotic course and 384 a long course. There was no significant difference in baseline characteristics of patients. The com posite primary outcome occurred in 61/384 patients in the long-treatment group (16%) versus 32/273 in the short-treatment group (12%) (p = 0.131). Mortality accounted for 41/384 (11%) versus 25/273 (9%) of cases, respectively. Length of hospital stay was signif icantly shorter in the short group [median 13 days, interquartile range (IQR) 9–21 days, versus median 15 days, IQR 11–26 days, p = 0.002]. Ten patients in the long group dis continued antibiotic therapy owing to adverse events, compared with none in the short group. On univariate and multivariate analyses, dura tion of therapy was not associated with the primary outcome. Conclusions: In this retrospective study, 6–- 10 days of antibiotic course for P. aeruginosa bacteremia were as effective as longer courses in terms of survival and recurrence. Shorter ther apy was associated with reduced length of stay and less drug discontinuation. |
Citation | Babich, T., Naucler, P., Valik, J.K., Giske, C.G., Benito, N., Cardona, R.,...,Yahav, D. (2022). Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study. INFECTIOUS DISEASES AND THERAPY, 11 (4), 1505-1519. https://doi.org/10.1007/s40121-022-00657-1. |
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