Article
The RhoB small GTPase in physiology and disease
Author/s | Vega Moreno, Francisco Manuel
![]() ![]() ![]() ![]() ![]() ![]() ![]() Ridley, Anne J. |
Department | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica |
Publication Date | 2016-10-23 |
Deposit Date | 2023-10-23 |
Published in |
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Abstract | RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in
cells. Its unique C-terminal region is subject to specific post-translational modifications that confer
different ... RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review. |
Citation | Vega Moreno, F.M. y Ridley, A.J. (2016). The RhoB small GTPase in physiology and disease. Small GTPases, 9 (5), 384-393. https://doi.org/10.1080/21541248.2016.1253528. |
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