Artículo
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Autor/es | Zhang, Qiang
Pizzorno, Andrés Miorin, Lisa Bastard, Paul Gervais, Adrián Le Voyer, Tom Retamar Gentil, Pilar Sánchez Céspedes, Javier Cordero Matia, María Elisa Casanova, Jean-Laurent |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2022 |
Fecha de depósito | 2023-10-06 |
Publicado en |
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Resumen | Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine
disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five ... Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6–73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-α2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-ω. The patients’ autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 × 10−5 ), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-α2 and IFN-ω (OR = 11.7, P = 1.3 × 10−5 ), especially those <70 yr old (OR = 139.9, P = 3.1 × 10−10). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for ∼5% of cases of life threatening influenza pneumonia in patients <70 yr old. |
Cita | Zhang, Q., Pizzorno, A., Miorin, L., Bastard, P., Gervais, A., Le Voyer, T.,...,Casanova, J. (2022). Autoantibodies against type I IFNs in patients with critical influenza pneumonia. JOURNAL OF EXPERIMENTAL MEDICINE, 219 (11), e20220514. https://doi.org/10.1084/jem.20220514. |
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