Article
Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells
Author/s | Jiménez Madrona, Enrique
Morado Díaz, Camilo José ![]() ![]() ![]() ![]() ![]() ![]() Talaverón Aguilocho, Rocío ![]() ![]() ![]() ![]() ![]() ![]() Tabernero, Arantxa Pastor Loro, Ángel Manuel ![]() ![]() ![]() ![]() ![]() ![]() ![]() Sáez, Juan C. Rodríguez Matarredona, Esperanza ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Departamento de Fisiología Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular |
Publication Date | 2023 |
Deposit Date | 2023-08-18 |
Published in |
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Abstract | The subventricular zone (SVZ) is a brain region that contains
neural stem cells and progenitor cells (NSCs/NPCs) from which new neurons
and glial cells are formed during adulthood in mammals. Recent data indicate
that ... The subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which new neurons and glial cells are formed during adulthood in mammals. Recent data indicate that SVZ NSCs are the cell type that acquires the initial tumorigenic mutation in glioblastoma (GBM), the most aggressive form of malignant glioma. NSCs/NPCs of the SVZ present hemichannel activity whose function has not yet been fully elucidated. In this work, we aimed to analyze whether hemichannel-mediated communication affects proliferation of SVZ NPCs and GBM cells. |
Funding agencies | Universidad de Sevilla |
Project ID. | US-VII PPIT
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Citation | Jiménez Madrona, E., Morado Díaz, C.J., Talaverón Aguilocho, R., Tabernero, A., Pastor Loro, Á.M., Sáez, J.C. y Rodríguez Matarredona, E. (2023). Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells. Frontiers in Neuroscience, 17, 1211467. https://doi.org/10.3389/fnins.2023.1211467. |
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