Article
Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales
Author/s | Escudero Cuadrado, Luis María
![]() ![]() ![]() ![]() ![]() ![]() ![]() Tagua Jáñez, Antonio Schamberger, Barbara Ziege, Ricardo Anselme, Karine Ben Amar, Martine Bykowski, Michał Castro, André P.G Dunlop, John W.C |
Department | Universidad de Sevilla. Departamento de Biología Celular |
Publication Date | 2023-03-29 |
Deposit Date | 2023-08-03 |
Published in |
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Abstract | Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology is ... Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology is supported by numerous experimental and theoretical investigations in recent years. In this review, first, a brief introduction to the key ideas of surface curvature in the context of biological systems is given and the challenges that arise when measuring surface curvature are discussed. Giving an overview of the emergence of curvature in biological systems, its significance at different length scales becomes apparent. On the other hand, summarizing current findings also shows that both single cells and entire cell sheets, tissues or organisms respond to curvature by modulating their shape and their migration behavior. Finally, the interplay between the distribution of morphogens or micro-organisms and the emergence of curvature across length scales is addressed with examples demonstrating these key mechanistic principles of morphogenesis. Overall, this review highlights that curved interfaces are not merely a passive by-product of the chemical, biological, and mechanical processes but that curvature acts also as a signal that co-determines these processes. © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH. |
Funding agencies | Fundação para a Ciência e a Tecnologia. Portugal Luxembourg National Research Fund European Research Council (ERC) Netherlands Organization for Scientific Research French National Research Agency Australian Research Council Deutsche Forschungsgemeinschaft (DFG) Ministerio de Ciencia e Innovación (MICIN). España |
Project ID. | 2020.04417
![]() A17/MS/11572821/MBRACE ![]() 851960 ![]() 024.003.013 ![]() ANR-201-8-CE1-3-0008 ![]() DP200102593 ![]() CI 203/-2 1 ![]() PID2021- 123013O-BI00 ![]() |
Citation | Escudero Cuadrado, L.M., Tagua Jáñez, A., Schamberger, B., Ziege, R., Anselme, K., Ben Amar, M.,...,Dunlop, J.W.C. (2023). Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales. Advanced Materials, 35 (13). https://doi.org/10.1002/adma.202206110. |
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