Artículo
Fluorescent calixarene-schiff as a nanovehicle with biomedical purposes
Autor/es | Lebrón Romero, José Antonio
Moyá Morán, María Luisa López López, Manuel Deasy, M. Muñoz Wic, Ana García Calderón, Clara Beatriz Valle Rosado, Iván Bernal Pérez, Eva Ostos Marcos, Francisco José López-Cornejo, María del Pilar |
Departamento | Universidad de Sevilla. Departamento de Química Física Universidad de Sevilla. Departamento de Genética Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2022-07-14 |
Fecha de depósito | 2023-06-26 |
Publicado en |
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Resumen | Gene therapy is a technique that is currently under expansion and development. Recent advances in genetic medicine have paved the way for a broader range of therapies and laid the groundwork for next-generation technologies. ... Gene therapy is a technique that is currently under expansion and development. Recent advances in genetic medicine have paved the way for a broader range of therapies and laid the groundwork for next-generation technologies. A terminally substituted difluorene-diester Schiff Base calix[4]arene has been studied in this work as possible nanovector to be used in gene therapy. Changes to luminescent behavior of the calixarene macrocycle are reported in the presence of ct-DNA. The calixarene macrocycle interacts with calf thymus DNA (ct-DNA), generating changes in its conformation. Partial double-strand denaturation is induced at low concentrations of the calixarene, resulting in compaction of the ct-DNA. However, interaction between calixarene molecules themselves takes place at high calixarene concentrations, favoring the decompaction of the polynucleotide. Based on cytotoxicity studies, the calixarene macrocycle investigated has the potential to be used as a nanovehicle and improve the therapeutic efficacy of pharmacological agents against tumors. |
Agencias financiadoras | Junta de Andalucía. Consejería de Conocimiento, Innovación y Universidades Universidad de Sevilla European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) European Commission. Fondo Social Europeo (FSO) Organización Nacional de Ciegos Españoles (ONCE) |
Identificador del proyecto | FQM-206
FQM-274 PY20-01234 PP2019/00000748 RTI2018-100692-B-100 P18-RT-1271 PI18-0005-2018 VIPP AY.SUPLEM-2019 RYC-2015-18670 |
Cita | Lebrón Romero, J.A., Moyá Morán, M.L., López López, M., Deasy, M., Muñoz Wic, A., García Calderón, C.B.,...,López-Cornejo, M.d.P. (2022). Fluorescent calixarene-schiff as a nanovehicle with biomedical purposes. Chemosensors, 10 (7), 281. https://doi.org/10.3390/chemosensors10070281. |
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chemosensors-10-00281-v4.pdf | 3.913Mb | [PDF] | Ver/ | Artículo |