Artículo
Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases
Autor/es | Koropouli, Eleftheria
Wang, Qiang Mejías Estévez, Rebeca María Hand, Randal Wang, Tao Ginty, David D. Kolodkin, Alex L. |
Departamento | Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2023 |
Fecha de depósito | 2023-06-07 |
Publicado en |
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Resumen | Secreted semaphorin 3F (Sema3F) and semaphorin 3A (Sema3A) exhibit remarkably distinct effects on deep layer excitatory cortical pyramidal neurons; Sema3F mediates dendritic spine pruning, whereas Sema3A promotes the ... Secreted semaphorin 3F (Sema3F) and semaphorin 3A (Sema3A) exhibit remarkably distinct effects on deep layer excitatory cortical pyramidal neurons; Sema3F mediates dendritic spine pruning, whereas Sema3A promotes the elaboration of basal dendrites. Sema3F and Sema3A signal through distinct holoreceptors that include neuropilin-2 (Nrp2)/plexinA3 (PlexA3) and neuropi-lin-1 (Nrp1)/PlexA4, respectively. We find that Nrp2 and Nrp1 are S-palmitoylated in cortical neurons and that palmitoylation of select Nrp2 cysteines is required for its proper subcellular localization, cell surface clustering, and also for Sema3F/Nrp2-dependent dendritic spine pruning in cortical neurons, both in vitro and in vivo. Moreover, we show that the palmitoyl acyltransferase ZDHHC15 is required for Nrp2 palmitoylation and Sema3F/Nrp2-dependent dendritic spine pruning, but it is dispensable for Nrp1 palmitoylation and Sema3A/Nrp1-dependent basal dendritic elaboration. Therefore, palmi-toyl acyltransferase-substrate specificity is essential for establishing compartmentalized neuronal structure and functional responses to extrinsic guidance cues. |
Agencias financiadoras | National Institutes of Health |
Identificador del proyecto | MH100024-Project #3
R21NS085358 |
Cita | Koropouli, E., Wang, Q., Mejías Estévez, R.M., Hand, R., Wang, T., Ginty, D.D. y Kolodkin, A.L. (2023). Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases. eLife, 12. https://doi.org/10.7554/eLife.83217. |
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