Artículo
Enantioselective LC-MS/MS determination of antidepressants, β-blockers and metabolites in agricultural soil, compost and digested sewage sludge
Autor/es | Arenas Molina, Marina
Santos Morcillo, Juan Luis Martín Bueno, Julia Aparicio Gómez, Irene Alonso Álvarez, Esteban |
Departamento | Universidad de Sevilla. Departamento de Química Analítica |
Fecha de publicación | 2023 |
Fecha de depósito | 2023-06-06 |
Publicado en |
|
Premios | Premio Mensual Publicación Científica Destacada de la US. Escuela Politécnica Superior |
Resumen | In this work, an analytical method was optimised and validated for the simultaneous extraction and enantioselective determination of chiral β-blockers, antidepressants and two of their metabolites in agricultural soils, ... In this work, an analytical method was optimised and validated for the simultaneous extraction and enantioselective determination of chiral β-blockers, antidepressants and two of their metabolites in agricultural soils, compost and digested sludge. Sample treatment was based on ultrasound-assisted extraction and extract clean-up by dispersive solid-phase extraction. Analytical determination was carried out by liquid chromatography-tandem mass spectrometry using a chiral column. Enantiomeric resolutions were in the range from 0.71 to 1.36. Accuracy was in the range from 85 to 127% and precision, expressed as relative standard deviation, was lower than 17% for all the compounds. Method quantification limits were below 1.21–52.9 ng g−1 dry weight (dw) in soil, 0.76–35.8 ng g−1 dw in compost and 13.6–90.3 ng g−1 dw in digested sludge. Application to real samples revealed enantiomeric enrichment in the range especially in compost and digested sludge (enantiomeric fractions up to 1). |
Agencias financiadoras | Junta de Andalucía Ministerio de Universidades. España |
Identificador del proyecto | US-1254283
FPU20/00540 |
Cita | Arenas Molina, M., Santos Morcillo, J.L., Martín Bueno, J., Aparicio Gómez, I. y Alonso Álvarez, E. (2023). Enantioselective LC-MS/MS determination of antidepressants, β-blockers and metabolites in agricultural soil, compost and digested sewage sludge. Analytica Chimica Acta, 1261. https://doi.org/10.1016/j.aca.2023.341224. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Enantioselective LC-MSMS.pdf | 2.961Mb | [PDF] | Ver/ | |