Article
Photoperiod Conditions Modulate Serum Oxylipins Levels in Healthy and Obese Rats: Impact of Proanthocyanidins and Gut Microbiota
Author/s | Arreaza Gil, Verónica
Ávila Román, Francisco Javier Escobar Martínez, Iván Muguerza, Begoña Suárez, Manuel Arola Arnal, Anna Torres Fuentes, Cristina |
Department | Universidad de Sevilla. Departamento de Farmacología |
Publication Date | 2023 |
Deposit Date | 2023-05-12 |
Published in |
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Abstract | Seasonal rhythms are emerging as a key factor influencing gut microbiota and bioactive compounds functionality as well as several physiological processes such as inflammation. In this regard, their impact on the modulation ... Seasonal rhythms are emerging as a key factor influencing gut microbiota and bioactive compounds functionality as well as several physiological processes such as inflammation. In this regard, their impact on the modulation of oxylipins (OXLs), which are important lipid mediators of inflammatory processes, has not been investigated yet. Hence, we aimed to investigate the effects of photoperiods on OXLs metabolites in healthy and obesogenic conditions. Moreover, we evaluated if the impact of proanthocyanidins and gut microbiota on OXLs metabolism is influenced by photoperiod in obesity. To this purpose, Fischer 344 rats were housed under different photoperiod conditions (L6: 6 h light, L12: 12 h light or L18:18 h light) and fed either a standard chow diet (STD) or a cafeteria diet (CAF) for 9 weeks. During the last 4 weeks, obese rats were daily administered with an antibiotic cocktail (ABX), an oral dose of a grape seed proanthocyanidin extract (GSPE), or with their combination. CAF feeding and ABX treatment affected OXLs in a photoperiod dependent-manner. GSPE significantly altered prostaglandin E2 (PGE2) levels, only under L6 and mitigated ABX-mediated effects only under L18. In conclusion, photoperiods affect OXLs levels influenced by gut microbiota. This is the first time that the effects of photoperiod on OXLs metabolites have been demonstrated. |
Funding agencies | Ministerio de Ciencia e Innovación (MICIN). España Diputación de Tarragona Universitat Rovira i Virgili. España |
Project ID. | AGL2016-77105-R
2021PGR-DIPTA-URV09 PMF-PIPF-35 EJ2018-002778-A |
Citation | Arreaza Gil, V., Ávila Román, F.J., Escobar Martínez, I., Muguerza, B., Suárez, M., Arola Arnal, A. y Torres Fuentes, C. (2023). Photoperiod Conditions Modulate Serum Oxylipins Levels in Healthy and Obese Rats: Impact of Proanthocyanidins and Gut Microbiota. Nutrients, 15 (3), 707. https://doi.org/10.3390/nu15030707. |
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