Artículo
Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability
Autor/es | Calvo Gallego, José Luis
Manchado Morales, Pablo Pivonka, Peter Martínez Reina, Francisco Javier |
Departamento | Universidad de Sevilla. Departamento de Ingeniería Mecánica y de Fabricación |
Fecha de publicación | 2023 |
Fecha de depósito | 2023-05-04 |
Publicado en |
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Resumen | Here we developed a spatio-temporal bone remodeling model to simulate the action of Basic Multicelluar Units (BMUs). This model is based on two major extensions of a temporal-only bone cell population model (BCPM). First, ... Here we developed a spatio-temporal bone remodeling model to simulate the action of Basic Multicelluar Units (BMUs). This model is based on two major extensions of a temporal-only bone cell population model (BCPM). First, the differentiation into mature resorbing osteoclasts and mature forming osteoblasts from their respective precursor cells was modelled as an intermittent process based on precursor cells availability. Second, the interaction between neighbouring BMUs was considered based on a “metabolic cost” argument which warrants that no new BMU will be activated in the neighbourhood of an existing BMU. With the proposed model we have simulated the phases of the remodelling process obtaining average periods similar to those found in the literature: resorption ((Formula presented.) days)—reversal (∼8 days)—formation (∼65 days)—quiescence (560–600 days) and an average BMU activation frequency of ∼1.6 BMUs/year/mm3. We further show here that the resorption and formation phases of the BMU become coordinated only by the presence of TGF-β (transforming growth factor β), i.e., a major coupling factor stored in the bone matrix. TGF-β is released through resorption so upregulating osteoclast apoptosis and accumulation of osteoblast precursors, i.e., facilitating the transition from the resorption to the formation phase at a given remodelling site. Finally, we demonstrate that this model can explain targeted bone remodelling as the BMUs are steered towards damaged bone areas in order to commence bone matrix repair. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Agencia Estatal de Investigación. España Consejo Australiano de Investigación |
Identificador del proyecto | PID2019-106969R
10.13039/501100011033 IC190100020 DP230101404 |
Cita | Calvo Gallego, J.L., Manchado Morales, P., Pivonka, P. y Martínez Reina, F.J. (2023). Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability. Frontiers in Bioengineering and Biotechnology, 11, 1060158. https://doi.org/10.3389/fbioe.2023.1060158. |
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