Article
Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
Author/s | López Jiménez, Elena
González Aguilera, Cristina |
Department | Universidad de Sevilla. Departamento de Biología Celular |
Publication Date | 2022 |
Deposit Date | 2023-04-17 |
Published in |
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Abstract | Chromatin organization is essential to maintain a correct regulation of gene expression
and establish cell identity. However, during cell division, the replication of the genetic material
produces a global disorganization ... Chromatin organization is essential to maintain a correct regulation of gene expression and establish cell identity. However, during cell division, the replication of the genetic material produces a global disorganization of chromatin structure. In this paper, we describe the new scientific breakthroughs that have revealed the nature of the post-replicative chromatin and the mechanisms that facilitate its restoration. Moreover, we highlight the implications of these chromatin alterations in gene expression control and their impact on key biological processes, such as cell differentiation, cell reprogramming or human diseases linked to cell proliferation, such as cancer. |
Funding agencies | Ministerio de Ciencia e Innovación (MICIN). España |
Project ID. | PID2019-105742GA-100
![]() RYC2018-025485-I ![]() |
Citation | López Jiménez, E. y González Aguilera, C. (2022). Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease. Genes, 13 (6). https://doi.org/10.3390/genes13061002. |
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