Article
Virological outcome among HiV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)
Author/s | Beltrán-Pávez, Carolina
Gutiérrez-López, Miguel Rubio-Garrido, Marina Valadés-Alcaraz, Ana Prieto, Luis Ramos, José Tomás López Cortés, Luis Fernando |
Department | Universidad de Sevilla.Departamento de Medicina |
Publication Date | 2020 |
Deposit Date | 2023-04-13 |
Published in |
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Abstract | The aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid ... The aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid Cohort of HIV-infected children and adolescents in Spain. We included 106 non-transferred and 184 transferred patients under clinical follow-up in 17 public hospitals in Madrid by the end of December 2017. Virological and immunological outcomes were compared in transferred vs. non-transferred patients. ART drug resistance mutations and HIV-variants were analyzed in all subjects with available resistance pol genotypes and/or genotypic resistance profiles. Among the study cohort, 133 (72.3%) of 184 transferred and 75 (70.7%) of 106 non-transferred patients had available resistance genotypes. Most (88.9%) of transferred had ART experience at sampling. A third (33.3%) had had a triple-class experience. Acquired drug resistance (ADR) prevalence was significantly higher in pretreated transferred than non-transferred patients (71.8% vs. 44%; p = 0.0009), mainly to NRTI (72.8% vs. 31.1%; p < 0.0001) and PI (29.1% vs. 12%; p = 0.0262). HIV-1 non-B variants were less frequent in transferred vs. non-transferred (6.9% vs. 32%; p < 0.0001). In conclusion, the frequent resistant genotypes found in transferred youths justifies the reinforcement of HIV resistance monitoring after the transition to avoid future therapeutic failures. |
Project ID. | PI15/01005-RIS_EPICLIN-02/2016 |
Citation | Beltrán-Pávez, C., Gutiérrez-López, M., Rubio-Garrido, M., Valadés-Alcaraz, A., Prieto, L., Ramos, J.T. y López Cortés, L.F. (2020). Virological outcome among HiV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017). Scientific Reports, 93 (6), 355-357. https://doi.org/10.1016/j.anpedi.2020.09.017. |