Cp₂TiCl/H₂O as a Sustainable System for the Reduction of Organic Functional Groups: Potential Application of Cp2TiCl/D2O to the Analysis of Bioactive Phenols in Olive Oil

Abstract

Significant efforts have been made toward developing sustainable reduction reactions of organic and bioorganic compounds. In these studies, the selection of reagents and solvents has played a very important role in the development of environment-friendly methodologies. In this context, the reducing agent Cp₂TiCl/H₂O has been introduced as a safe, efficient, selective, and low-cost reagent, and thus as a sustainable alternative for the reduction of organic compounds. To facilitate understanding of the reductions mediated by this system, in this study we focus on describing the intermediates, mechanisms, and representative examples. Finally, a reflection is made on the future perspectives of this reducing agent, including its analog Cp₂TiCl/D₂O as a powerful tool for the preparation of deuterated phenols, which can be successfully used as an internal standard for analyzing bioactive phenols in olive oil.