Artículo
Drug-loaded PCL electrospun nanofibers as anti-pancreatic cancer drug delivery systems
Autor/es | Mitxelena-Iribarren, Oihane
Riera-Pons, Marc Pereira Arenas, Sheila Calero-Castro, Francisco José Castillo Tuñón, Juan Manuel Padillo Ruiz, Francisco Javier Mujika, Maite Arana, Sergio |
Departamento | Universidad de Sevilla. Departamento de Cirugía |
Fecha de publicación | 2022-08-13 |
Fecha de depósito | 2023-04-10 |
Publicado en |
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Resumen | Cancer is one of the main causes of death worldwide, being pancreatic cancer the
second deadliest cancer in Western countries. Surgery, chemotherapy and radiotherapy
form the basis of pancreatic cancer’s current treatment. ... Cancer is one of the main causes of death worldwide, being pancreatic cancer the second deadliest cancer in Western countries. Surgery, chemotherapy and radiotherapy form the basis of pancreatic cancer’s current treatment. However, these techniques have several disadvantages, such as surgery complications, chemotherapy systemic side effects and cancer recurrence. Drug delivery systems can reduce side effects, increasing the effectivity of the treatment by a controlled release at the targeted tumor cells. In this context, coaxial electrospun fibers can increase the control on the release profile of the drug. The aim of this study was to encapsulate and release different anticancer drugs (5-Fluorouracil and Methotrexate) from a polymeric fiber mat. Different flows and ratios were used to test their effect on fiber morphology, FTIR spectrum, drug encapsulation and release. Good integration of the anticancer drugs was observed and the use of a desiccator for 24 h showed to be a key step to remove solvent remanence. Moreover, the results of this study demonstrated that the polymeric solution could be used to encapsulate and release different drugs to treat cancers. This makes coaxial electrospinning a promising alternative to deliver complex chemotherapies that involve more than one drug, such as FOLFIRINOX, used in pancreatic cancer treatment. |
Cita | Mitxelena-Iribarren, O., Riera-Pons, M., Pereira Arenas, S., Calero-Castro, F.J., Castillo Tuñón, J.M., Padillo Ruiz, F.J.,...,Arana, S. (2022). Drug-loaded PCL electrospun nanofibers as anti-pancreatic cancer drug delivery systems. POLYMER BULLETIN. https://doi.org/10.1007/s00289-022-04425-6. |
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