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Expression of P-glycoprotein and metallothionein in gastrointestinal stromal tumor and leiomyosarcomas. Clinical implications
dc.creator | Pérez Gutiérrez, Sofía | es |
dc.creator | González Cámpora, Ricardo | es |
dc.creator | Amérigo Navarro, Joaquín | es |
dc.creator | Beato Moreno, Antonio | es |
dc.creator | Sánchez León, María | es |
dc.creator | Pareja Megía, Jesús María | es |
dc.creator | Virizuela Echaburu, Juan Antonio | es |
dc.creator | López Beltrán, Antonio | es |
dc.date.accessioned | 2023-03-08T12:33:06Z | |
dc.date.available | 2023-03-08T12:33:06Z | |
dc.date.issued | 2007-07-10 | |
dc.identifier.citation | Pérez Gutiérrez, S., González Cámpora, R., Amérigo Navarro, J., Beato Moreno, A., Sánchez León, M., Pareja Megía, J.M.,...,López Beltrán, A. (2007). Expression of P-glycoprotein and metallothionein in gastrointestinal stromal tumor and leiomyosarcomas. Clinical implications. Pathology Oncology Research, 13 (3), 203-208. https://doi.org/10.1007/BF02893500. | |
dc.identifier.issn | 1219-4956 | es |
dc.identifier.issn | 1532-2807 | es |
dc.identifier.uri | https://hdl.handle.net/11441/143232 | |
dc.description.abstract | We investigated the expression of P-glycoprotein (P-GP) and metallothionein (MT) in a series of 92 GIST and 14 gastrointestinal leiomyosarcomas (GILMS) with the purpose to expand our knowledge on the biological bases of GIST chemo-resistance and to ascertain their significance in patients’ prognosis. P-GP expression was more frequent in GIST than in GI-LMS (83.7% vs. 21.4%, p<0.001), with no difference between low- and high-risk GIST (p=1.000) or low- and high-grade GI-LMS (p=0.538). P-GP expression was unrelated to anatomic location (gastric vs. intestinal) in GIST (39/45 vs. 35/43, p=0.770) and in GI-LMS (0/2 vs. 2/6, p=1.000). MT expression was non-significantly higher in GI-LMS than in GIST (35.7% vs. 14.1%, p=0.060), with no difference between low- and high-risk GIST (p=1.000) or low- and high-grade GI-LMS (p=1.000). MT expression was unrelated to the anatomic location (gastric vs. intestinal) in GIST (7/45 vs. 6/43) and GI-LMS (0/2 vs. 1/6) (p=1.000 and p=0.1000, respectively). Overall tumor-specific survival (p< 0.001) and disease-free survival (p<0.001) were different in GIST as compared with GI-LMS, and the number of events was higher in GI-LMS. When the survival analysis took into consideration P-GP or MT expression, the overall survival in GIST was influenced by the expression of MT (p=0.021) but not by that of P-GP (p=0.638). However, in GI-LMS, P-GP expression influenced disease-free survival (p=0.050); in addition, it is important to recognize the limited value of these results because of the low number of cases involved in the study. Differential expression of P-GP and MT might explain the known variability in response to systemic chemotherapy in these tumors. Detection of P-GP and MT seems to add certain prognostic value in GIST (MT) or GI-LMS (P-GP). | es |
dc.format | application/pdf | es |
dc.format.extent | 7 p. | es |
dc.language.iso | eng | es |
dc.publisher | Proquest | es |
dc.relation.ispartof | Pathology Oncology Research, 13 (3), 203-208. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | gastrointestinal stromal tumors | es |
dc.subject | GIST | es |
dc.subject | leiomyosarcomas | es |
dc.subject | P-glycoprotein | es |
dc.subject | metallothionein | es |
dc.title | Expression of P-glycoprotein and metallothionein in gastrointestinal stromal tumor and leiomyosarcomas. Clinical implications | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estadística e Investigación Operativa | es |
dc.relation.publisherversion | https://dx.doi.org/10.1007/BF02893500 | es |
dc.identifier.doi | 10.1007/BF02893500 | es |
dc.contributor.group | Universidad de Sevilla. FQM153: Estadística e Investigación Operativa | es |
dc.journaltitle | Pathology Oncology Research | es |
dc.publication.volumen | 13 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 203 | es |
dc.publication.endPage | 208 | es |