Artículo
Acute oxidant damage promoted on cancer cells by amitriptyline in comparison with some common chemotherapeutic drugs
Autor/es | Cordero, Mario David
Sánchez-Alcázar, José Antonio Bautista-Ferrufino, María Rosa Carmona-López, María Inés Illanes, Matilde Alcudia Cruz, Ana Miguel Rodríguez, Manuel de |
Departamento | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica |
Fecha de publicación | 2010 |
Fecha de depósito | 2023-03-06 |
Publicado en |
|
Resumen | Oxidative therapy is a relatively new anticancer strategy
based on the induction of high levels of oxidative stress,
achieved by increasing intracellular reactive oxygen
species (ROS) and/or by depleting the ... Oxidative therapy is a relatively new anticancer strategy based on the induction of high levels of oxidative stress, achieved by increasing intracellular reactive oxygen species (ROS) and/or by depleting the protective antioxidant machinery of tumor cells. We focused our investigations on the antitumoral potential of amitriptyline in three human tumor cell lines: H460 (lung cancer), HeLa (cervical cancer), and HepG2 (hepatoma); comparing the cytotoxic effect of amitriptyline with three commonly used chemotherapeutic drugs: camptothecin, doxorubicin, and methotrexate. We evaluated apoptosis, ROS production, mitochondrial mass and activity, and antioxidant defenses of tumor cells. Our results show that amitriptyline produces the highest cellular damage, inducing high levels of ROS followed by irreversible serious mitochondrial damage. Interestingly, an unexpected decrease in antioxidant machinery was observed only for amitriptyline. In conclusion, based on the capacity of generating ROS and inhibiting antioxidants in tumor cells, amitriptyline emerges as a promising new drug to be tested for anticancer therapy. |
Cita | Cordero, M.D., Sánchez-Alcázar, J.A., Bautista-Ferrufino, M.R., Carmona-López, M.I., Illanes, M., Alcudia Cruz, A. y Miguel Rodríguez, M.d. (2010). Acute oxidant damage promoted on cancer cells by amitriptyline in comparison with some common chemotherapeutic drugs. Anti-Cancer Drugs. https://doi.org/10.1097/CAD.0b013e32833ed5f7. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Acute oxidant...pdf | 364.3Kb | [PDF] | Ver/ | |
Este registro aparece en las siguientes colecciones
Este documento está protegido por los derechos de propiedad intelectual e industrial. Sin perjuicio de las exenciones legales existentes, queda prohibida su reproducción, distribución, comunicación pública o transformación sin la autorización del titular de los derechos, a menos que se indique lo contrario.