Artículo
Modelling the Unfolding Pathway of Biomolecules: Theoretical Approach and Experimental Prospect
Autor/es | Plata Ramos, Carlos Alberto
Prados Montaño, Antonio |
Departamento | Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear |
Fecha de publicación | 2018 |
Fecha de depósito | 2023-02-22 |
Publicado en |
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Resumen | We analyse the unfolding pathway of biomolecules comprising several independent modules in pulling experiments. In a recently proposed model, a critical velocity vc
has been predicted, such that for pulling speeds v>vc
... We analyse the unfolding pathway of biomolecules comprising several independent modules in pulling experiments. In a recently proposed model, a critical velocity vc has been predicted, such that for pulling speeds v>vc it is the module at the pulled end that opens first, whereas for v<vc it is the weakest. Here, we introduce a variant of the model that is closer to the experimental setup, and discuss the robustness of the emergence of the critical velocity and its dependence on the model parameters. We also propose a possible experiment to test the theoretical predictions of the model, which seems feasible with state-of-art molecular engineering techniques. |
Cita | Plata Ramos, C.A. y Prados Montaño, A. (2018). Modelling the Unfolding Pathway of Biomolecules: Theoretical Approach and Experimental Prospect. Springer Proceedings in Mathematics & Statistics, 232, 137-151. https://doi.org/10.1007/978-3-319-76599-0_8. |
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