Artículo
Catalytic Enantioselective Synthesis of a-aryl a-hydrazino Esters and Amides
Autor/es | Velázquez Muñoz, Marta
Alberca Manzano, Saúl Iglesias Sigüenza, Francisco Javier Fernández Fernández, Rosario Fátima Lassaletta, José M Monge Fernández, David |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2020 |
Fecha de depósito | 2022-11-29 |
Publicado en |
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Resumen | Catalysts generated by combinations of Pd(TFA)2and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids toN-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding ... Catalysts generated by combinations of Pd(TFA)2and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids toN-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding a-aryl a-hydrazino esters/amides in high enantioselectivities. Subsequent removal of the carbamoyl moiety affords key building blocks en route to hydrazinopeptides,N-aminopeptides and peptidomimetics thereof. |
Cita | Velázquez Muñoz, M., Alberca Manzano, S., Iglesias Sigüenza, F.J., Fernández Fernández, R.F., Lassaletta, J.M. y Monge Fernández, D. (2020). Catalytic Enantioselective Synthesis of a-aryl a-hydrazino Esters and Amides. Chemical Communications, 56 (43), 5823-5826. https://doi.org/10.1039/d0cc02478c. |
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