dc.creator | Cerrada Romero, Cristina | es |
dc.creator | Berastegui-Cabrera, Judith | es |
dc.creator | Camacho-Martínez, Pedro | es |
dc.creator | Goikoetxea Aguirre, Josune | es |
dc.creator | Pérez Palacios, Patricia | es |
dc.creator | Santibáñez, Sonia | es |
dc.creator | Pascual Hernández, Álvaro | es |
dc.creator | Pachón Díaz, Jerónimo | es |
dc.creator | Cordero Matia, María Elisa | es |
dc.creator | Sánchez Céspedes, Javier | es |
dc.date.accessioned | 2022-11-21T15:47:17Z | |
dc.date.available | 2022-11-21T15:47:17Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Cerrada Romero, C., Berastegui-Cabrera, J., Camacho-Martínez, P., Goikoetxea Aguirre, J., Pérez Palacios, P., Santibáñez, S.,...,Sánchez Céspedes, J. (2022). Excretion and viability of SARS‑CoV‑2 in feces and its association with the clinical outcome of COVID‑19. Scientific Reports, 12 (1), 7397. https://doi.org/10.1038/s41598-022-11439-7. | |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139633 | |
dc.description.abstract | The main objective was to evaluate the viability of the SARS-CoV-2 viral particles excreted in stools.
In addition, we aimed to identify clinical factors associated with the detection of SARS-CoV-2 RNA in
feces, and to determine if its presence is associated with an unfavorable clinical outcome, defned as
intensive care unit (ICU) admission and/or death. A prospective multicenter cohort study of COVID-19
adult patients, with confrmed SARS-CoV-2 infection by RT-PCR assay in nasopharyngeal (NP) swabs
admitted to four hospitals in Spain, from March 2020 to February 2021. Sixty-two adult COVID-19
patients had stool samples collected at admission and/or during the follow up, with a total of 79 stool
samples. SARS-CoV-2 RNA was detected in stool samples from 27 (43.5%) out of the 62 patients.
Replicative virus, measured by the generation of cytopathic efect in cell culture and subsequent
RT-PCR confrmation of a decrease in the Ct values, was not found in any of these stool samples. Fecal
virus excretion was not associated with the presence of gastrointestinal symptoms, or with diferences
in the evolution of COVID-19 patients. Our results suggest that SARS-CoV-2 replicative capacity
is null or very limited in stool samples, and thus, the fecal–oral transmission of SARS-CoV-2 as an
alternative infection route is highly unlikely. In our study, the detection of SARS-CoV-2 RNA in feces at
the beginning of the disease is not associated with any clinical factor nor with an unfavorable clinical
outcome. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Scientific Reports, 12 (1), 7397. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | SARS-CoV-2 | es |
dc.subject | COVID-19 | es |
dc.subject | Feces | es |
dc.title | Excretion and viability of SARS‑CoV‑2 in feces and its association with the clinical outcome of COVID‑19 | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-022-11439-7 | es |
dc.identifier.doi | 10.1038/s41598-022-11439-7 | es |
dc.journaltitle | Scientific Reports | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 7397 | es |