Artículo
Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin
Autor/es | Flores Cordero, Juan Antonio
Pérez Pérez, Antonio Jiménez Cortegana, Carlos Alba Jiménez, Gonzalo Flores-Barragán, Alfonso Sánchez Margalet, Víctor |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-11-17 |
Publicado en |
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Resumen | Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases ... Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases in obesity and has central actions not only at the hypothalamic level but also in other regions and nuclei of the central nervous system (CNS) such as the cerebral cortex and hippocampus. These regions express the long form of leptin receptor LepRb, which is the unique leptin receptor capable of transmitting complete leptin signaling, and are the first regions to be affected by chronic neurocognitive deficits, such as mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). In this review, we discuss different leptin resistance mechanisms that could be implicated in increasing the risk of developing AD, as leptin resistance is frequently associated with obesity, which is a chronic low-grade inflammatory state, and obesity is considered a risk factor for AD. Key players of leptin resistance are SOCS3, PTP1B, and TCPTP whose signalling is related to inflammation and could be worsened in AD. However, some data are controversial, and it is necessary to further investigate the underlying mechanisms of the AD-causing pathological processes and how altered leptin signalling affects such processes. |
Agencias financiadoras | Plan Andaluz de Investigación, Desarrollo e Innovación, Junta de Andalucía |
Identificador del proyecto | PAIDI CTS-151 |
Cita | Flores Cordero, J.A., Pérez Pérez, A., Jiménez Cortegana, C., Alba Jiménez, G., Flores-Barragán, A. y Sánchez Margalet, V. (2022). Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin. International Journal of Molecular Sciences, 23 (9), 5202. https://doi.org/10.3390/ijms23095202. |
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Obesity Risk.pdf | 1.348Mb | [PDF] | Ver/ | |